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Zimmerli and Allegretti et al. show, in fission yeast, that nuclear pores constrict under energy deprivation or osmotic stress, which is linked to a reduction in nuclear membrane tension.
DNA damage accumulation in zebrafish neurons during wakefulness is detected by Parp1, which induces a homeostatic drive to sleep and repair the damage.
Prachee Avasthi highlights how a 1969 study by Rosenbaum and colleagues on Chlamydomonas provided a framework for the understanding of the structure and function of cilia.
Entry of SARS-CoV-2 into host cells is mediated by the interaction between the viral spike protein and its receptor angiotensin-converting enzyme 2, followed by virus–cell membrane fusion. Worldwide research efforts have provided a detailed understanding of this process at the structural and cellular levels, enabling successful vaccine development for a rapid response to the COVID-19 pandemic.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their RNA genomes. Recent studies have improved our understanding of coronavirus RNA translation, replication and transcription, and offer new therapeutic targets.
Machine learning is becoming a widely used tool for the analysis of biological data. However, for experimentalists, proper use of machine learning methods can be challenging. This Review provides an overview of machine learning techniques and provides guidance on their applications in biology.
Dietary restriction in rodents and non-human primates affects key nutrient-sensing signalling pathways to increase healthspan and lifespan. This Review discusses these geroprotective mechanisms and recent insights suggesting that dietary restriction results in similar molecular and metabolic changes in humans, contributing to the prevention of ageing-associated diseases.
This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with cancer. Insights into these regulatory mechanisms are creating new opportunities for the treatment of cancer.
