Volume 18 Issue 3, March 2017

Volume 18 Issue 3

'Spotlight on dynamic telomeres' by Vicky Summersby, inspired by the Review on p175.

Research Highlights

  • Research Highlight |

    The microRNA mir-34a has a key role in restricting the developmental potential of mouse pluripotent stem cells to embryonic cell types.

    • Kim Baumann
  • Research Highlight |

    In mice, the absence of maternal Trim28 expression in early male embryos causes loss of DNA methylation and derepression of a non-imprinted gene, which results in lethality.

    • Eytan Zlotorynski
  • Research Highlight |

    DNA damage-induced histone degradation results in decreased nucleosome occupancy, which promotes homologous recombination by enhancing the dynamicity of chromatin.

    • Paulina Strzyz
  • Journal Club

  • Journal Club |

    Caroline Dean discusses the mechanisms underlying the storage and inheritance of epigenetic memory.

    • Caroline Dean
  • Research Highlight |

    A zinc finger protein is shown to bind to telomeres and mediate telomere trimming, thereby preventing potentially detrimental telomere lengthening.

    • Eytan Zlotorynski

Reviews

  • Review Article |

    Histone chaperones safeguard the chromatin template and shield histones from promiscuous interactions to ensure their proper storage, transport, post-translational modification, nucleosome assembly and turnover.

    • Colin M. Hammond
    • , Caroline B. Strømme
    • , Hongda Huang
    • , Dinshaw J. Patel
    •  & Anja Groth
  • Review Article |

    In response to steroid ligands, glucocorticoid receptor (GR) activates or represses gene expression in a highly context-specific manner. New evidence suggests that the conformation of GR is allosterically modulated by contextual signals, including DNA sequences, ligands, post-translational modifications and other transcription regulators, and that this supports the assembly of distinct transcription complexes.

    • Emily R. Weikum
    • , Matthew T. Knuesel
    • , Eric A. Ortlund
    •  & Keith R. Yamamoto
  • Review Article |

    Telomere shortening and loss of telomere protection can have a tumour-suppressive effect by mediating proliferation arrest. Ultimately, however, these processes can cause a state of extensive genome instability known as telomere crisis, which can facilitate tumorigenesis by causing oncogenic chromosomal rearrangements, including chromothripsis, kataegis and tetraploidization.

    • John Maciejowski
    •  & Titia de Lange
  • Review Article |

    Three microtubule nucleation pathways — initiated from centrosomes, chromatin and existing spindle microtubules — contribute to the assembly of a functional mitotic spindle in animal cells to ensure accurate chromosome segregation. Recent findings have shed light on their relative contributions to building the spindle and on adaptation of the spindle to variations in cell size and shape.

    • Suzanna L. Prosser
    •  & Laurence Pelletier

Perspectives