Volume 14 Issue 6, June 2013

Volume 14 Issue 6

'Stem cells on standby' by Vicky Summersby, inspired by the Review on p329.

Research Highlights

Reviews

  • Review Article |

    Subsets of mammalian adult stem cells reside in a reversible quiescent state. Recent studies of epigenetic, transcriptional and post-transcriptional events underlying quiescence suggest that this state is actively maintained by signalling pathways that keep cells poised for rapid activation, rather than this being a dormant state with minimal basal activity.

    • Tom H. Cheung
    •  & Thomas A. Rando
  • Review Article |

    The methylation of cytosine bases in DNA has a key role in regulating transcription. It has recently been discovered that ten-eleven translocation (TET) proteins can reverse DNA methylation, refining our view of how changes in DNA methylation are coupled to different cellular processes.

    • William A. Pastor
    • , L. Aravind
    •  & Anjana Rao
  • Review Article |

    Pluripotent stem cell lines differ in their capacity to differentiate into desired cell types in vitro. Genetic and epigenetic variations contribute to functional variability between cell lines and heterogeneity within single clones. Characterizing such variations is important for the use of pluripotent stem cells in disease modelling and developmental processes and for their applications in regenerative medicine.

    • Patrick Cahan
    •  & George Q. Daley
  • Review Article |

    Through their role as substrate adaptors for S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin ligase complexes, F-box proteins control the degradation of a large number of proteins with wide-ranging functions. Studying the mechanisms of substrate recruitment by F-box proteins has increased our understanding of their dysregulation in disease and might lead to targeted therapies.

    • Jeffrey R. Skaar
    • , Julia K. Pagan
    •  & Michele Pagano
  • Review Article |

    The distinct organization of the endoplasmic reticulum (ER)–Golgi interface across species reflects variation in the mechanisms that control transport between these organelles. Continued comparative analyses of this interface should help to elucidate the ways that ER–Golgi trafficking control can be adapted to meet cell type-specific needs.

    • Federica Brandizzi
    •  & Charles Barlowe

Perspectives

    Viewpoint

  • Viewpoint |

    The past few years have marked significant anniversaries in the field of signal transduction. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.

    • Nancy E. Hynes
    • , Philip W. Ingham
    • , Wendell A. Lim
    • , Christopher J. Marshall
    • , Joan Massagué
    •  & Tony Pawson