Volume 12 Issue 5, May 2011

From The Editors

Research Highlights

Reviews

  • Review Article |

    Transcription termination is one of the least-understood processes in gene expression. However, recent studies have revealed common themes and principles between models of RNA polymerase II (Pol II) termination, including the poly(A)-dependent and Sen1-dependent pathways, and provided insight into the role of Pol II carboxy-terminal domain phosphorylation in this process.

    • Jason N. Kuehner
    • , Erika L. Pearson
    •  & Claire Moore
  • Review Article |

    In the ubiquitin network, a multitude of ubiquitin species is constantly decoded by ubiquitin-binding domains. To properly coordinate biological events, ubiquitylation depends on strict spatiotemporal regulation, which is achieved by compartmentalization, sequential series of ubiquitylation events and crosstalk with other post-translational modifications.

    • Caroline Grabbe
    • , Koraljka Husnjak
    •  & Ivan Dikic
  • Review Article |

    Cells exist within a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. Disrupting these cues compromises tensional homeostasis, which suggests that there is complex interplay between the extracellular microenvironment and cellular function. As alterations in the extracellular matrix can sustain perturbed tensional homeostasis, it serves as a mechanically based memory-storage device.

    • Christopher C. DuFort
    • , Matthew J. Paszek
    •  & Valerie M. Weaver
  • Review Article |

    Centromeric chromatin differs from bulk chromatin in many aspects, including a distinct organization and the presence of different histone variants. Studies have focused on elucidating the molecular and physical architecture of centromeric chromatin, as well as the properties that make it invaluable during chromosome segregation in mitosis.

    • Jolien S. Verdaasdonk
    •  & Kerry Bloom

Perspectives

    Timeline

  • Timeline |

    In 1971, Günter Blobel and David Sabatini formulated the signal hypothesis, which proposed that proteins contain signal sequences that target them for secretion. Over the past 40 years this concept has expanded, and topogenic signals are now known to target proteins to many parts of the cell.

    • Karl S. Matlin