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  • Scientists are captivated by the prospect of creating a fully synthetic cell, offering the potential to revolutionize biology, medicine and biotechnology. In this Viewpoint, a panel of experts discusses the definitions of a synthetic cell and highlights current achievements, challenges and future opportunities of building such systems.

    • Katarzyna P. Adamala
    • Marileen Dogterom
    • T-Y Dora Tang
    Viewpoint
  • Embedded within the complexity of biological systems lies a formidable task: deciphering the intricate architecture of macromolecules. In this Viewpoint, a panel of experts discuss the key challenges and opportunities of macromolecular structure determination, highlighting the crucial synergy between empirical experimentation and artificial intelligence-based techniques in unravelling these complexities.

    • Xiao-chen Bai
    • Tamir Gonen
    • Jianyi Yang
    Viewpoint
  • In this Viewpoint article, experts provide their current opinions on heterochromatin definition, types and functional mechanisms.

    • Oliver Bell
    • Adam Burton
    • Maria-Elena Torres-Padilla
    Viewpoint