News & Comment

A new study shows that the chaperonin TRiC is required for TCAB1 folding in the telomerase biogenesis pathway.

Two papers inSciencenow provide insights into the highly regulated interface of the cohesin complex and a potential DNA exit gate.

Five papers report extensive transcriptomic, epigenomic and proteomic analyses of reprogramming, revealing the existence of several reprogramming routes and multiple unique pluripotent cell states.

The signal recognition particle (SRP) interacts with nascent polypeptides and assists protein translocation across membranes. Pechmannet al. identified that downstream non-optimal codons in the mRNA attenuate translation and promote SRP binding.

Betzig and colleagues created ultrathin light sheets to visualize dynamic processes at high speed and high spatiotemporal resolution.

Robinet al. describe telomere position effect over long distances (TPE–OLD), a phenomenon in which long (but not short) telomeres control gene expression by forming chromatin loops with genes located several Mb away.

Increased organization of the ECM mediated by myofibroblast remodelling pre-conditions for TGFβ activation.

A protocol for the large-scale differentiation of human pluripotent stem cells into functional β cells has been developed.

Two studies report the design of DNA hairpins that function as optical probes of cellular traction forces, offering high spatiotemporal resolution and signal-to-noise ratio.

The ten-eleven-tanslocation (TET) family of proteins regulates enhancer methylation and activity in embryonic stem cells.

Angiogenic factors induce podosome rosettes in endothelial cells that mediate focal degradation of the basement membrane and blood vessel branching.

Fat cadherins are required for the function of the electron transport chain.

The Asi complex defines an ERAD branch that is specific for inner nuclear membrane protein quality control in yeast.

Using a system that offers high temporal resolution of transcription in single living cells, Stasevichet al. reveal that histone H3 Lys 27 acetylation enhances gene expression by promoting transcription elongation and transcription factor recruitment.

Kazutoshi Mori and Peter Walter were awarded the 2014 Albert Lasker Basic Medical Research Award for their discoveries on the unfolded protein response.

VLK is identified as the first extracellular Tyr kinase. It targets extracellular proteins and those in the secretory pathway.

PTEN maintains chromosome condensation by interacting with histone H1.

Lobopodial migration is driven by increased hydrostatic pressure in the cell anterior as a result of forward motion of the nucleus.

RIPK1 can inhibit apoptosis and necroptosis through a kinase-independent scaffolding function, which is important for maintaining epithelial homeostasis.

The size reduction ofXenopus laevisnuclei during development is controlled by increased nuclear localization and activity of conventional protein kinase C (cPKC).