News & Comment

  • Research Highlight |

    Glycoproteins of the glycocalyx are shown to have the capacity to bend the plasma membrane.

    • Paulina Strzyz
  • Research Highlight |

    Editing the protein sequence of the transcription factor SKN-1A/Nrf1 regulates its function and the expression of proteasome subunits.

    • Kim Baumann
  • Research Highlight |

    Glucose deprivation induces ER stress, which enhances mitochondrial respiration by promoting the assembly of respiratory supercomplexes.

    • Paulina Strzyz
  • Journal Club |

    Susana Godinho discusses a 1996 paper by Heald et al. on the organization of microtubules into bipolar spindles.

    • Susana A. Godinho
  • Journal Club |

    Jesús Gil discusses the first evidence for cellular senescence being associated with ageing, and how these studies opened new routes for basic and translational research.

    • Jesús Gil
  • Comment |

    Michael Levin and colleagues discuss the need to rethink how the causes of cell biological processes are being identified.

    • Mariano Bizzarri
    • , Douglas E. Brash
    • , James Briscoe
    • , Verônica A. Grieneisen
    • , Claudio D. Stern
    •  & Michael Levin
  • Research Highlight |

    The serotonylation of histone H3 Gln5 promotes transcription of neuronal genes during neuronal cell differentiation, by potentiating the binding to promoters of the transcription factor TFIID.

    • Eytan Zlotorynski
  • Research Highlight |

    A group of mesenchymal stem cell transcription factors promotes osteogenesis and represses adipogenesis.

    • Kim Baumann
  • Research Highlight |

    Two studies in Science show that biomolecular condensates of membrane-associated signalling complexes increase the residence of signalling effectors within these complexes.

    • Paulina Strzyz
  • Research Highlight |

    Two independent studies from Science report that hypoxia causes histone hypermethylation by direct modulation of histone lysine demethylases.

    • Paulina Strzyz
  • Journal Club |

    Channing Der and Kirsten Bryant discuss recent work leading towards therapeutic targeting of autophagy in pancreatic cancer.

    • Kirsten L. Bryant
    •  & Channing J. Der
  • Research Highlight |

    DNA replication of under-replicated loci can occur after mitosis in 53BP1-contaning nuclear bodies and is required for genome stability.

    • Anne Mirabella
  • Research Highlight |

    Four studies provide new insights into the mechanism, functions and regulation of the cGAS–STING pathway.

    • Paulina Strzyz
  • Research Highlight |

    High-throughput FISH analysis reveals that chromatin interactions are highly variable between cells and between alleles in individual cells.

    • Eytan Zlotorynski
  • Research Highlight |

    Three studies provide new insights into the mechanisms responsible for genome remodelling and changes in gene expression associated with senescence.

    • Paulina Strzyz
  • Research Highlight |

    Lipin 1 and ARF1 control SREBP trafficking, processing and activity to regulate lipid synthesis in response to mechanical cues from the extracellular matrix.

    • Grant Otto
  • Research Highlight |

    Cells can efficiently invade the tissue in the absence of metalloproteinases by physically breaching the basement membrane.

    • Paulina Strzyz
  • Research Highlight |

    Cells in telomere crisis undergo cell death through autophagy, which is triggered by chromosome breakage and transduced by the cGAS–STING pathway.

    • Eytan Zlotorynski
  • Research Highlight |

    Palmitoylation-driven partitioning of importin-α at the plasma membrane contributes to intracellular scaling.

    • Paulina Strzyz
  • Research Highlight |

    Single-cell allelic expression analysis reveals that enhancers predominantly modulate the frequency of transcription bursts whereas core promoters affect their size.

    • Grant Otto
  • Research Highlight |

    ORP2 is a lipid transfer protein that exchanges cholesterol for phosphatidylinositol-4,5-bisphosphate at the plasma membrane.

    • Grant Otto
  • Research Highlight |

    A plant complex comprising SUVH1, SUVH3, DNAJ1 and DNAJ2 counteracts DNA-methylation-mediated silencing of transposon-neighbouring genes.

    • Eytan Zlotorynski
  • Research Highlight |

    Mitochondrial dynamics regulates stem cell expansion and differentiation.

    • Paulina Strzyz
  • Research Highlight |

    STELLA protects the genome of mouse oocytes from de novo DNA methylation by the E3 ubiquitin ligase UHRF1 and the DNA methyltransferase DNMT1.

    • Kim Baumann
  • Research Highlight |

    DNA N6-adenosine methylation is a transgenerational epigenetic modification that confers mitochondrial stress adaptation in the nematode Caenorhabditis elegans.

    • Grant Otto
  • Journal Club |

    David Barford discusses how the template model for MAD2 activation in the spindle assembly checkpoint represented a new concept for generating and propagating intracellular signals.

    • David Barford
  • Research Highlight |

    The RNA-binding protein TIS11B forms a membraneless organelle, the TIS granule, in an endoplasmic reticulum (ER) subdomain termed the TIS granule–ER (TIGER) domain, which facilitates 3ʹ UTR-mediated protein–protein interactions that regulate protein trafficking.

    • Grant Otto
  • Research Highlight |

    The first demonstration of a mechanism for active sorting of anterograde cargo in the Golgi via protein palmitoylation.

    • Paulina Strzyz
  • Research Highlight |

    Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.

    • Grant Otto
  • Research Highlight |

    Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.

    • Eytan Zlotorynski
  • Research Highlight |

    Endothelial cells in white adipose tissue communicate with adipocytes through extracellular vesicles, relaying systemic metabolic information.

    • Paulina Strzyz
  • Journal Club |

    Adriano Aguzzi discusses the endeavours of the Gitler team to identify the causes underlying the fatal human neurological disease amyotrophic lateral sclerosis (ALS).

    • Adriano Aguzzi
  • Research Highlight |

    DNA double-strand breaks at active genes are repaired by a dedicated homologous recombination mechanism involving R-loop formation and RAD52 recruitment.

    • Eytan Zlotorynski
  • Research Highlight |

    Nature Reviews Molecular Cell Biology congratulates the winners of the 2018 Lasker Foundation Awards.

    • Paulina Strzyz
  • Journal Club |

    The introduction of DNA-chain terminators for sequencing by Fred Sanger enabled the early genome sequencing projects.

    • George G. Brownlee
  • Research Highlight |

    The kinase ATR senses the completion of DNA replication and controls the S/G2 cell-cycle transition.

    • Michelle Trenkmann
  • Research Highlight |

    Direct demonstration that mutations in intrinsically disordered regions modulate protein–protein interaction networks, which may cause disease.

    • Paulina Strzyz
  • Research Highlight |

    3′uridylation by TUT4 and TUT7 is shown as a post-transcriptional mechanism restricting retrotransposition of LINE-1 elements and also replication of animal RNA viruses.

    • Paulina Strzyz
  • Research Highlight |

    A study reports that CRISPR–Cas9 induces extensive on-target mutagenesis in mouse and human cells, calling for greater caution when using it in clinical contexts.

    • Kim Baumann
  • Research Highlight |

    Poly(dA:dT) tracts characterize strong DNA replication origins in mammals and cause replication-fork collapse and DNA breaks that underlie the expression of fragile sites.

    • Eytan Zlotorynski
  • Research Highlight |

    A new study in Nature identifies a molecular axis linking diabetes to cancer, whereby AMPK, which is inhibited in high glucose conditions, regulates the stability of TET2 DNA demethylase, thereby impacting DNA methylation and gene expression.

    • Paulina Strzyz
  • Journal Club |

    Ueli Schibler explains why the phenotype of a mutation in a codon of the ‘21st amino acid’ selenium cysteine was unexpectedly specific.

    • Ueli Schibler
  • Research Highlight |

    Eliminating senescent cells by administering senolytic drugs can improve healthspan and lifespan in mice.

    • Kim Baumann
  • Journal Club |

    Rebecca Taylor discusses the elegance and importance of early discoveries from the Walter laboratory on the unfolded protein response, and why they have become landmark studies.

    • Rebecca C. Taylor
  • Comment |

    G protein coupled receptors (GPCRs) transmit a variety of signals, mostly by engaging G proteins, but G protein-independent signalling through arrestins has also been demonstrated. Based on recent experimental evidence, Gutkind and Kostenis argue that arrestins serve as important signal modulators instead of as independent signal transducers.

    • J. Silvio Gutkind
    •  & Evi Kostenis