Abstract
Extracellular matrix (ECM) proteins constitute >1% of the proteome and interact with many modifiers and growth factors to affect most aspects of cellular behaviour during development and normal physiology, as well as in diseases such as fibroses, cancer and many genetic disorders. In addition to biochemical signals provided to cells by ECM proteins, important cell–ECM interactions involve bidirectional mechanotransduction influences, which are dependent on the physical structure and organization of the ECM. These are beginning to be understood using twenty-first-century approaches, including biophysics, nanotechnology, biological engineering and modern microscopy. Articles in this issue of Nature Reviews Molecular Cell Biology review progress in our understanding of the ECM.
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References
Hay, E. D. (ed.) Cell Biology of Extracellular Matrix (Plenum Press, 1981).
Hynes, R. O. & Naba, A. Overview of the Matrisome — an inventory of extracellular matrix constituents and functions. Cold Spring Harb. Perspect. Biol. 4, a004903 (2012).
Hynes, R. O. & Yamada, K. M. (eds) Extracellular Matrix Biology (Cold Spring Harbor Lab. Press, 2012).
Mecham, R. P. (ed.) The Extracellular Matrix: an Overview (Springer, 2011).
Mouw, J., Ou, G. & Weaver, V. M. Extracellular matrix assembly: a multiscale deconstruction. Nature Rev. Mol. Cell. Biol. 15, 771–785 (2014).
Humphrey, J. D., Dufresne, E. R. & Schwartz, M. A. Mechanotransduction and extracellular matrix homeostasis. Nature Rev. Mol. Cell. Biol. 15, 802–812 (2014).
Iskratsch, T., Wolfenson, H. & Sheetz, M. P. Appreciating force and shape — the rise of mechanotransduction in cell biology. Nature Rev. Mol. Cell. Biol. 15, 825–833 (2014).
Folkman, J. & Moscona, A. Role of cell shape in growth control. Nature 273, 345–349 (1978).
Bonnans, C., Chou, J. & Werb, Z. Remodelling the extracellular matrix in development and disease. Nature Rev. Mol. Cell. Biol. 15, 786–801 (2014).
Charras, G. & Sahai, E. Physical influences of the extracellular environment on cell migration. Nature Rev. Mol. Cell. Biol. 15, 813–824 (2014).
Senger, D. R. & Davis, G. E. Angiogenesis. Cold Spring Harb. Perspect. Biol. 3, a005090 (2011).
Watt, F. M. & Huck, W. T. Role of the extracellular matrix in regulating stem cell fate. Nature Rev. Mol. Cell. Biol. 14, 467–473 (2013).
Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677–689 (2006).
Naba, A., Clauser, K. R., Lamar, J. M., Carr, S. A. & Hynes, R. O. Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters. eLife 3, e01308 (2014).
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Hynes, R. Stretching the boundaries of extracellular matrix research. Nat Rev Mol Cell Biol 15, 761–763 (2014). https://doi.org/10.1038/nrm3908
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DOI: https://doi.org/10.1038/nrm3908
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