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The RNA exosome and proteasome: common principles of degradation control

Nature Reviews Molecular Cell Biology volume 14, pages 654–660 (2013)Cite this article

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Abstract

Defective RNAs and proteins are swiftly degraded by cellular quality control mechanisms. A large fraction of their degradation is mediated by the exosome and the proteasome. These complexes have a similar architectural framework based on cylindrical, hollow structures that are conserved from bacteria and archaea to eukaryotes. Mechanistic similarities have also been identified for how RNAs and proteins are channelled into these structures and prepared for degradation. Insights gained from studies of the proteasome should now set the stage for elucidating the regulation, assembly and small-molecule inhibition of the exosome.

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Figure 1: The architecture of the core exosome and proteasome complexes.
Figure 2: Proteasome and exosome regulatory proteins bound to the core particles.

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Acknowledgements

The authors are grateful to W. Baumeister, F. Förster, J.Tittor, E. Kowalinski, S. Falk and members of their laboratory for discussions and critical comments.

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  1. Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152, Germany

    Debora L. Makino, Felix Halbach & Elena Conti

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  1. Debora L. Makino
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Correspondence to Debora L. Makino, Felix Halbach or Elena Conti.

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Makino, D., Halbach, F. & Conti, E. The RNA exosome and proteasome: common principles of degradation control. Nat Rev Mol Cell Biol 14, 654–660 (2013). https://doi.org/10.1038/nrm3657

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