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Blastoids (blastocyst-like structures) that accurately model human blastocyst development and are capable of implantation are generated, potentially opening up new avenues for basic and clinical research.
Kaneshige et al. show that skeletal muscle-resident mesenchymal progenitors relay the mechanical signal of muscle overload to muscle stem cells to induce their proliferation.
DNA damage accumulation in zebrafish neurons during wakefulness is detected by Parp1, which induces a homeostatic drive to sleep and repair the damage.
Lengefeld et al. show that haematopoietic stem cell enlargement explains, at least in part, the reduction of tissue regenerative potential with ageing.
Zimmerli and Allegretti et al. show, in fission yeast, that nuclear pores constrict under energy deprivation or osmotic stress, which is linked to a reduction in nuclear membrane tension.
Betti et al. show that plants can take up microRNAs generated by other plants, and that these exogenous miRNAs are active in silencing the expression of their target genes.
tiRNA-containing extracellular vesicles produced by osteoblasts in the bone marrow are taken up by granulocyte–monocyte progenitors, which promotes their proliferation, increasing host immunity.
Tau oligomers bind to m6A-modified RNA transcripts in the cytoplasm via the linker RNA-binding protein HNRNPA2B1; such complexes are found in individuals with Alzheimer disease and are part of a stress response that represses translation.
Suppressing ovulation protects against chromosomal abnormalities in ageing mouse oocytes, which can be partly explained by increasing REC8–cohesin retention on chromosomes.
The pathogenicity of SARS-CoV-2 and respiratory syncytial virus (RSV) involves mechanisms of liquid–liquid phase separation, which can be explored as targets for new antiviral therapeutics.
Apoptotic hair follicle stem cells contribute to tissue regeneration by producing WNT3, which promotes cell proliferation, enlarging the stem cell pool.
In response to replication stress, TOPBP1 is recruited by Treacle to nucleoli, where the two proteins facilitate the stress response and help maintain the transcription of rRNA genes.