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The ARP2/3 complex, which nucleates branched actin filament networks, is itself activated by nucleation-promoting factors (NPFs). New understanding is being gained into NPF control of ARP2/3 and the biological roles of ARP2/3 branched actin.
The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. The SEC controls transcription elongation in the presence or absence of promoter-proximal paused Pol II, and its gene target specificity depends on protein components forming distinct SEC complexes.
Successful abscission — the final stage of cell division — involves the precise coordination of different events, culminating in the separation of two daughter cells. Endocytic and secretory vesicle trafficking, ESCRT-mediated scission and signalling through mitotic kinases have emerged as key players in this process.
TBC/RABGAPs are negative regulators of RABs that carry a conserved TBC domain. In addition to their roles in intracellular trafficking, they have recently emerged as integrators of signalling between RABs and other small GTPases, and they are frequently dysregulated in disease.
