Volume 19 Issue 10, October 2019

Volume 19 Issue 10

‘Immunology of the bone’, inspired by the Review on p626

Cover design: Simon Bradbrook

Research Highlights

  • Research Highlight |

    A new study shows that monocytes, recruited to the lungs during an infection, sense alterations in physical forces and pressure and initiate a pro-inflammatory response. This environmental sensory axis is mediated by the mechanically activated calcium channel PIEZO1.

    • Lucy Bird
  • Research Highlight |

    Class-switch recombination was thought to take place in B cells that enter germinal centres, but this study shows that it actually occurs earlier than previously thought.

    • Alexandra Flemming
  • Research Highlight |

    The angiogenic growth factor placental growth factor is produced by TH17 cells and induces TH17 cell differentiation, which suggests a positive feedback loop between angiogenesis and autoimmunity in chronically inflamed tissues.

    • Kirsty Minton
  • Research Highlight |

    Targeting metabolism via mTOR restores suppressor functions in FOXP3-deficient regulatory T cells.

    • Yvonne Bordon
  • Research Highlight |

    Fasting can modulate immune responses in the context of infection, inflammatory disease and cancer.

    • Yvonne Bordon

Reviews

  • Review Article |

    This Review focuses on evidence implicating innate lymphoid cells (ILCs) as previously unappreciated regulators of the adaptive immune system. Reciprocal interactions between ILCs and adaptive immune cells are a crucial determinant of tissue immune responses during homeostasis and disease.

    • Gregory F. Sonnenberg
    •  & Matthew R. Hepworth
  • Review Article |

    New findings indicate that IFN-λ (type III IFN) has a non-redundant role in antiviral, antifungal and antiprotozoal defences of mucosal barriers that differs in several aspects from the functions of IFN-α and IFN-β (type I IFNs).

    • Liang Ye
    • , Daniel Schnepf
    •  & Peter Staeheli
  • Review Article |

    Mucosal-associated invariant T cells display innate, effector-like qualities and are involved, in various ways, in infectious and non-infectious diseases. Insights into their activation, tissue migration and function are revealing their beneficial and deleterious roles in disease.

    • Amine Toubal
    • , Isabelle Nel
    • , Sophie Lotersztajn
    •  & Agnès Lehuen