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A new study shows that monocytes, recruited to the lungs during an infection, sense alterations in physical forces and pressure and initiate a pro-inflammatory response. This environmental sensory axis is mediated by the mechanically activated calcium channel PIEZO1.
Class-switch recombination was thought to take place in B cells that enter germinal centres, but this study shows that it actually occurs earlier than previously thought.
The angiogenic growth factor placental growth factor is produced by TH17 cells and induces TH17 cell differentiation, which suggests a positive feedback loop between angiogenesis and autoimmunity in chronically inflamed tissues.
This Review focuses on evidence implicating innate lymphoid cells (ILCs) as previously unappreciated regulators of the adaptive immune system. Reciprocal interactions between ILCs and adaptive immune cells are a crucial determinant of tissue immune responses during homeostasis and disease.
New findings indicate that IFN-λ (type III IFN) has a non-redundant role in antiviral, antifungal and antiprotozoal defences of mucosal barriers that differs in several aspects from the functions of IFN-α and IFN-β (type I IFNs).
It is well known that immune cells can have profound effects on bone cells, but this interaction is not unidirectional. In this review, Tsukasaki and Takayanagi explore the reciprocal dialogue between bone cells and immune cells during health and disease.
Mucosal-associated invariant T cells display innate, effector-like qualities and are involved, in various ways, in infectious and non-infectious diseases. Insights into their activation, tissue migration and function are revealing their beneficial and deleterious roles in disease.
