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The long non-coding RNA NKILA sensitizes antitumour T cells to activation-induced cell death. Targeting this pathway can improve adoptive T cell therapy for cancer.
Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset.
This study supports the suspected autoimmune nature of narcolepsy by showing that patients have memory T cells targeting self-antigens expressed by hypocretin neurons.
Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
Eric Vivier and colleagues discuss the emerging roles for natural killer (NK) cells and other innate lymphoid cell populations in cancer immunity. The authors highlight the current immunotherapy trials that are targeting NK cells to treat patients with cancer.
This Review examines the functions of a specialized population of macrophages that make direct contact with or are found within one cell thickness of the abluminal surface of blood vessels in various tissues during both steady-state conditions and pathological processes.
This Review highlights the key roles of forkhead box transcription factors (FTFs) in regulating lymphocyte responses. The authors discuss how FTFs function as context-dependent rheostats, allowing lymphocytes to fine-tune their responses to diverse environmental challenges.
Can macrophages derived from induced pluripotent stem cells (iPSCs) be used to effectively model in vivo tissue macrophages? Here, the authors consider the pros and cons of the different protocols for generating macrophages from iPSCs and suggest that a two-step model, based on ontogeny and tissue-specific microenvironment, enables the generation of biologically relevant macrophages.
