Volume 18 Issue 11, November 2018

Volume 18 Issue 11

‘Macrophage allsorts’, inspired by the Review on p716

Cover design: Simon Bradbrook

Comment

Research Highlights

  • Research Highlight |

    Neutrophil extracellular traps awaken dormant cancer cells by remodelling the extracellular matrix.

    • Yvonne Bordon
  • Research Highlight |

    A quorum-sensing mechanism downregulates tissue inflammation by regulating metabolism in monocyte-derived cells.

    • Yvonne Bordon
  • Research Highlight |

    The long non-coding RNA NKILA sensitizes antitumour T cells to activation-induced cell death. Targeting this pathway can improve adoptive T cell therapy for cancer.

    • Lucy Bird
  • Journal Club |

    Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset.

    • Laura K. Mackay
  • Research Highlight |

    This study supports the suspected autoimmune nature of narcolepsy by showing that patients have memory T cells targeting self-antigens expressed by hypocretin neurons.

    • Kirsty Minton
  • Research Highlight |

    This study demonstrates that secreted IgD promotes protective humoral responses to soluble antigens such as food allergens.

    • Alexandra Flemming
  • Research Highlight |

    Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.

    • Lucy Bird

Reviews

  • Review Article |

    Eric Vivier and colleagues discuss the emerging roles for natural killer (NK) cells and other innate lymphoid cell populations in cancer immunity. The authors highlight the current immunotherapy trials that are targeting NK cells to treat patients with cancer.

    • Laura Chiossone
    • , Pierre-Yves Dumas
    • , Margaux Vienne
    •  & Eric Vivier
  • Review Article |

    This Review examines the functions of a specialized population of macrophages that make direct contact with or are found within one cell thickness of the abluminal surface of blood vessels in various tissues during both steady-state conditions and pathological processes.

    • Antonio Lapenna
    • , Michele De Palma
    •  & Claire E. Lewis

Perspectives

  • Perspective |

    Can macrophages derived from induced pluripotent stem cells (iPSCs) be used to effectively model in vivo tissue macrophages? Here, the authors consider the pros and cons of the different protocols for generating macrophages from iPSCs and suggest that a two-step model, based on ontogeny and tissue-specific microenvironment, enables the generation of biologically relevant macrophages.

    • Christopher Z. W. Lee
    • , Tatsuya Kozaki
    •  & Florent Ginhoux

Amendments & Corrections