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Jeffrey Pollard describes a 2003 study by Enzleret al. that identified the immune response against bacteria as preventing chronic inflammation-associated tumour development.
Nucleic acid-sensing receptors are crucial for initiating protective immune responses against viruses, but aberrant activation of these receptors can also drive pathological inflammation. In this Review, the authors discuss the new agonists and antagonists that are being developed to target these receptors in the clinic.
This Review provides an insightful discussion on the current concepts in multiple sclerosis research, including genetic predisposition and environmental triggers, and explores the evolving link between inflammation and neurodegeneration. The authors highlight the clinical challenges and key questions that remain to be addressed.
The cytoskeleton is important for both cell structure and cell function. In this Review, the authors summarize the emerging roles of cytoskeletal components in sensing and eliminating bacterial pathogens from host cells.
T cell differentiation and metabolism are intimately linked. This article describes how T cell receptor-induced transcription factors cooperate with canonical nutrient-sensing pathways to integrate antigen-specific and metabolic signals and appropriately modulate adaptive immune responses.
The enormous potential offered by chromatin profiling to reveal the past, present and future activity of a cell, as well as its ability to respond to the tissue environment, warrants the widespread use of this technique in immunological research.
