News & Comment

B cells may protect against pre-term labour by responding to IL-33.

Expression of CX₃CR1 defines a new memory T cell subset that surveys peripheral tissues.

Pollutants activate the aryl hydrocarbon receptor to upregulate type 2 cytokines and neurotrophic factors that drive atopic dermatitis.

Thymic stromal lymphopoietin increases the killing of methicillin-resistantStaphylococcus aureusin a neutrophil- and complement-dependent manner.

The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications.

Andrew Pollard describes a 1921 study by George Heist and colleagues that pointed to antibody as a correlate of protection against meningococcal disease.

Two studies have characterized a distinct molecular signature of intratumoral CD4⁺regulatory T cells from various tumours that correlates with cancer prognosis.

Macrophages expressing PPARγ support skeletal muscle regeneration by inducing secretion of the myoblast growth factor GDF3.

A cell-intrinsic checkpoint restricts type 2 cytokine production by ILC2s and T_H2 cells at sites of tissue damage.

Type I interferons induced by chronic viral infections suppress the induction of early neutralizing antibody responses.

Multinuclear granuloma macrophages arise through a distinct differentiation pathway mediated by chronic TLR2 signalling, rather than by cell fusion.

Broadly neutralizing human antibodies for Zika virus protect adult mice and prevent maternal–fetal transmission.

Alan Sher describes a 2002 paper by Martien Kapsenberg and Pawel Kalinski that provided evidence for the conditioning of DCs by microbial compounds to promote T_H1 or T_H2 cell responses.

Macrophages regulate phagocytic and inflammatory responses by non-professional phagocytes.

Immunologists appreciate the need for creative approaches to tackle complex scientific questions, which can involve not only the use of novel technologies but also the experience of scientists from diverse backgrounds. Here, we highlight measures to prime for the inclusion of women and underrepresented individuals in science to boost immunology research.

Antibodies from individuals with latent and active tuberculosis infections show distinct glycosylation patterns and Fc-dependent effector functions.

Epithelium-derived butyrophilin-like (BTNL) molecules can shape the local γδ T cell repertoire in a tissue-specific manner.

T follicular regulatory cells suppress antibody production through the induction of a unique suppressive state in T follicular helper cells and B cells.