News & Comment

A quorum-sensing mechanism downregulates tissue inflammation by regulating metabolism in monocyte-derived cells.

Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.

This study supports the suspected autoimmune nature of narcolepsy by showing that patients have memory T cells targeting self-antigens expressed by hypocretin neurons.

In this comment, Maziar Divangahi discusses the roles of disease tolerance and trained immunity in tuberculosis infection.

T cells are engineered to home specifically to brain tumours.

Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset.

Naive CD4⁺ T cells are prepared for rapid activation and metabolic remodelling through the derepression of a poised translational machinery, which occurs independently of nutrient-sensing pathways.

Bacterially primed T cells reactive against heat shock proteins enter the eye and cause neurodegeneration in glaucoma.

Infant immune systems are highly diverse at birth but then show convergence in the first three months of life.

Neutrophil cytoplasts promote T helper 17 cell responses that propagate neutrophilic inflammation in severe asthma.

Autologous T cell–tumour organoid co-cultures provide a minimally invasive method to study patient-specific antitumour immune responses.

A regulatory B cell subset has been identified that is characterized by the expression of LAG3. In response to TLR stimulation, these LAG3⁺ B cells produce IL-10.

RNA degradasome components metabolize mitochondrial double-stranded RNA and prevent aberrant activation of innate sensors in the cytosol.

Adrian Liston describes two papers by Nicole Le Douarin and colleagues from the 1980s that used a chick–quail graft system to show the existence of dominant T cell tolerance.

A combination of TORC1 inhibitors increases immune responses to vaccines and decreases overall infection rates in the elderly.

Scientists involved in the Human Cell Atlas Project describe its potential as a resource for future research and the challenges that lie ahead.

Macrophage priming by inflammatory stimuli drives the new synthesis and oxidation of mitochondrial DNA, which is essential for NLRP3 inflammasome activation.

Two papers published in Nature introduce a new subset of medullary thymic epithelial cells with properties similar to intestinal tuft cells, including IL-25 production and chemosensing ability.

New role for IgE identified in protection against epithelial cell damage and tumorigenesis.

Jeffrey Bluestone describes a 1987 study of anergic T cells by Marc Jenkins and Ron Schwartz that altered his thoughts about T cell tolerance and eventually gave birth to the field of checkpoint inhibition.