News & Comment

Two groups have shown that personalized, neoantigen-based tumour vaccines elicit effective T cell responses in patients with advanced melanoma, leading to favourable clinical outcomes. Combination with checkpoint blockade can be of additional benefit.

Obesity associated non-alcoholic fatty liver disease is associated with pro-fibrotic type 2 immune responses

Intracellular and secreted isoforms of osteopontin differentially regulate myeloid progenitors and differentiated lymphoid cells, respectively, through pro- and anti-apoptotic effects.

Fetal dendritic cells suppress pro-inflammatory T cell activity.

Lambda interferons have a non-redundant role in protecting airway epithelial cells from influenza A virus infection without inducing immunopathology.

Regulatory T cells modulate the hair follicle regeneration cycle by inducing stem cell proliferation and differentiation.

Ephrin B1 controls T follicular helper cell residence and function in germinal centres.

Sphingosine 1-phosphate promotes naive T cell survival by supporting their mitochondrial function.

T-bet⁺ regulatory T cells form a stable subset with specific suppressive activity towards T-bet⁺effector T cells.

Anti-LAP antibodies show promising anticancer properties.

Ashley Moffett describes a 1995 paper by Colonna and Samaridis that provided the stimulus to understanding the link between NK cells and pre-eclampsia.

Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell–B cell collaboration for antibody production.

Anne Cooke discusses a 1989 paper by Don Mason and colleagues that described a role for adrenal corticosteroids in modulating autoimmune pathology.

Rhinovirus infections exacerbate asthma by inducing the release of neutrophil extracellular traps.

The anti-inflammatory effects of IL-10 involve mTORC1-regulated metabolic and autophagic pathways in macrophages.

Activation of TGFβ by platelets limits the efficacy of anti-tumour T cell responses.

Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment.