News & Comment

The long-term survival of HIV-1-infected CD4⁺ T cells is shown to be controlled by the anti-apoptotic protein BIRC5 and its upstream regulator OX40, which suggests new therapeutic targets to reduce the size of the viral reservoir.

A high-fibre diet protects against influenza virus infection by limiting lung immunopathology and enhancing antiviral T cell responses.

CYPD regulates the host response to tuberculosis infection through modulating T cell metabolism.

Activation of aryl hydrocarbon receptor in phago cytes during apoptotic cell uptake induces an anti-inflammatory response.

A host-derived long non-coding RNA limits antiviral type I interferon responses by binding to and inhibiting RIG-I activation.

TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.

The metabolite itaconate induces electrophilic stress that induces an antioxidant response and regulates secondary TLR transcriptional responses and IL-17-driven pathology.

γδ T cells have a crucial role in immune homeostasis and thermogenesis in adipose tissues through their production of IL-17A and TNF.

Microglial cells show innate immune memory of peripheral inflammatory stimuli that influences neurological disease pathology.

Natural influenza virus infection in humans induces protective neuraminidase-reactive antibodies that are not induced by current influenza vaccines.

SAMHD1 promotes the degradation of nascent DNA strands to protect against aberrant activation of the pro-inflammatory cGAS–STING pathway by self DNA.

Norovirus infection of tuft cells in the intestinal epithelium can be promoted by type 2 cytokines.

Strain-specific recognition of different UL40 peptides determines the proliferation and activation of NKG2C⁺ NK cells during HCMV infection.

The immunomodulatory drug dimethyl fumarate blocks GAPDH and aerobic glycolysis in activated immune cells.

Itaconate alkylates KEAP1 to regulate NRF2 activity and induce an anti-inflammatory response in macrophages

Proteolytic cleavage of IL-33 by environmental allergens induces rapid induction of allergic type 2 inflammation.

NRP1-deficient macrophages show impaired fatty acid oxidation.

The ubiquitin ligase activity of CBL proteins controls the exit of B cells from the germinal centre to become plasma cells.

Hyperglycaemia directly mediates dysfunction of the intestinal epithelial barrier in obesity, leading to increased translocation of microbial products.

Sensory neurons in the lungs suppress immune responses to bacterial lung infections.