The long-term survival of HIV-1-infected CD4+ T cells is shown to be controlled by the anti-apoptotic protein BIRC5 and its upstream regulator OX40, which suggests new therapeutic targets to reduce the size of the viral reservoir.
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Original article
Kuo, H.-H. et al. Anti-apoptotic protein BIRC5 maintains survival of HIV-1-infected CD4+ T cells. Immunity https://doi.org/10.1016/j.immuni.2018.04.004 (2018)
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Minton, K. Cheating cell death. Nat Rev Immunol 18, 418–419 (2018). https://doi.org/10.1038/s41577-018-0026-2
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DOI: https://doi.org/10.1038/s41577-018-0026-2
