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A preprint by Lad et al. shows that tumour-associated neutrophils in glioblastoma originate from skull bone marrow and acquire an antigen-presenting cell phenotype intratumorally in the presence of local T cells.
Copper(ii) ions promote the metabolic and epigenetic remodelling of macrophages towards a pro-inflammatory state. A copper-binding metformin dimer showed promising results in mouse models of inflammation.
A preprint by Mahadevan et al. shows that pancreatitis alters the immune landscape of mice with pancreatic ductal adenocarcinoma and highlights a role for dendritic cells in promoting responses to immune checkpoint blockade.
A preprint by Rodríguez-Silvestre et al. describes a mechanism for the export of antigens from endosomes regulated by perforin 2, for cross-presentation by dendritic cells.
Probiotic gut bacteria can translocate to and persist in melanomas where they stimulate antitumour CD8+ T cells through the production of immunomodulatory metabolites.
In this Comment article, the authors argue that recent reports showing effects of sodium on cellular immunometabolism support an expansion of the definition of salt sensitivity beyond effects on blood pressure.
Chronic stress in mice induces microbial dysbiosis and affects the differentiation of γδ T cells in the colon. These cells accumulate in the meninges and cause depression-like behaviour, which can be reversed by targeting the pattern recognition receptor dectin-1.
At high doses, the dietary sweetener sucralose interferes with T cell receptor signalling, impairing antitumour and antibacterial T cell responses in mice.