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A preprint by Kwok et al. describes the identification of common neojunction-derived antigens that could serve as targets for ‘off the shelf’ vaccines or adoptive cell therapies for patients with various types of cancer.
The failure of T cell-targeted vaccines for HIV in clinical trials is likely due to impaired degranulation of low-avidity CD8+ T cells in the context of low levels of antigen presentation.
In this Comment article, the authors alert us to recent studies of ancient DNA that advance our understanding of the origins of autoimmune disease, providing evidence that our disease risk has been shaped by pathogen-driven evolution.
A study published in Immunity shows that the mechanical force experienced by neutrophils migrating across endothelial barriers arms them for better bactericidal activity.
Genetic variants are identified in humans and viruses that influence the development of multiple sclerosis by shaping protective natural killer cell responses.