Articles in 2016

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  • Memory B cells are produced early, whereas long-lived plasma cells are produced late, in the germinal centre response.

    • Olive Leavy
    Research Highlight

  • This Review focuses on our growing understanding of immunological memory behaviour in natural killer (NK) cells. The authors discuss the development and functions of memory NK cells and consider the potential of targeting these populations for vaccination or therapeutic purposes.

    • Adelheid Cerwenka
    • Lewis L. Lanier
    Review Article

  • Downregulation of the T-box transcription factors eomesodermin (EOMES) and T-bet drives tissue-resident memory T cell fate.

    • Olive Leavy
    Research Highlight

  • Peter Doherty describes the 1962 paper by Jim Gowans that characterized lymphocyte-mediated immunity.

    • Peter Doherty
    Journal Club

  • Decreased cholesterol metabolism in response to virus infection potentiates the type I interferon-mediated antiviral response.

    • Kirsty Minton
    Research Highlight

  • The development and maintenance of protective CD8+ T cell memory require help. This is provided by CD4+ T cells in many ways. Here, the authors review the latest insights into this multifaceted role for CD4+T cells, and the implications for vaccine design and T cell-based therapies.

    • Brian J. Laidlaw
    • Joseph E. Craft
    • Susan M. Kaech
    Review Article