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In this Review, the authors illustrate how computational modelling can complement experimental research to understand highly complex signalling networks in T cells. They explain how computational approaches can help to eliminate incorrect hypotheses, generate new hypotheses, reveal gaps in our knowledge and design better experiments.
This Review article describes the variety of mechanisms that regulate the production of protein and lipid mediators of inflammation through effects on translation initiation and mRNA decay, with an emphasis on mechanisms that link the initiation and resolution phases of inflammation.
The soil nematodeCaenorhabditis elegans is easy to manipulate genetically and is therefore a useful model organism. But C. elegansdoes not use its Toll-like receptor homologue for immune defence. So what can it tell us about the origins and functions of other immune defence pathways in higher organisms?