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A preprint by Lozano-Rabella et al. uses a proteogenomics approach to identify an underappreciated class of non-canonical tumour ligands shared across tumours.
A preprint by Daniels et al. reports a sex-specific role for the microglial protein CST7 in the regulation of phagocytosis and inflammatory signalling.
A preprint by Beltra et al. describes a role for STAT5A in the development of an intermediate-exhausted ‘effector-like’ phenotype of exhausted T cells.
A preprint by Ma et al. investigates the mechanism of antigen spreading induced by a vaccine-boosted CAR T cell approach, which has implications for the therapeutic challenges associated with tumour heterogeneity or tumour antigen loss.
A preprint by Martinez-Riano et al. evaluates the dynamics of antigen retention by follicular dendritic cells (FDCs) in germinal centres, showing that immune complexes accumulate in the centre of the FDC network.
A preprint by Buquicchio et al. looks at the chromatin landscape of memory CD8+ T cells over the course of their development during acute and chronic viral infections.
A preprint by Cheng et al. describes how differential expression of the X-chromosome-encoded epigenetic regulator UTX contributes to sex-based differences in natural killer cell frequency and function.
A preprint by Ho et al. investigates the role of decreased CD58 expression in cancer cell immune evasion, through both lack of T cell co-stimulation and increased T cell inhibition.
A preprint by Mosallanejad et al. uses a comparative immunology approach to investigate the catalytic domains of cGAS, showing that reactivity to self-DNA is not conserved across mammalian species.
A preprint by Baer et al. looks at the role of pancreas tissue-resident macrophages in pancreatic tissue injury and fibrosis during pancreatitis and pancreatic ductal adenocarcinoma.
A preprint by Kedmi et al. shows that antigen presentation by group 3 innate lymphoid cells is involved in directing the microbiome-specific adaptive immune response by promoting regulatory T cells.
A preprint by Daniel et al. reports a novel, late-stage phenotype of exhausted T cells that occurs concurrently with terminally differentiated exhausted T cells, determined by T cell receptor affinity for antigen.
A preprint by Ukita et al. describes a role for CXCL13-producing T helper cells in promoting the formation of tertiary lymphoid structures in ovarian cancer that are associated with improved clinical outcome.
A preprint by Jerby-Arnon et al. uses a novel algorithm for scRNAseq data to describe a pan-cancer programme for dysfunctional tumour-infiltrating lymphocytes that predicts response to immune checkpoint blockade therapy.
A preprint by Sanin et al. establishes a transcriptional framework to define common macrophage activation states across tissues and biological conditions.
A preprint by Kersten et al. describes a positive-feedback loop promoting the mutual formation of tumour-associated macrophages and exhausted T cells as they move towards the tumour core.
Shane Crotty discusses three independent studies published in 2009 that characterized T follicular helper cells as a distinct subset of CD4+ T cells on the basis of selective expression of BCL6.
