Browse Articles

Jeffrey Pollard describes a 2003 study by Enzleret al. that identified the immune response against bacteria as preventing chronic inflammation-associated tumour development.

T cell differentiation and metabolism are intimately linked. This article describes how T cell receptor-induced transcription factors cooperate with canonical nutrient-sensing pathways to integrate antigen-specific and metabolic signals and appropriately modulate adaptive immune responses.

The enormous potential offered by chromatin profiling to reveal the past, present and future activity of a cell, as well as its ability to respond to the tissue environment, warrants the widespread use of this technique in immunological research.

Tumour suppressor p53 promotes immune tolerance by clearing apoptotic cells and upregulating immune checkpoint molecules.

This Review provides an insightful discussion on the current concepts in multiple sclerosis research, including genetic predisposition and environmental triggers, and explores the evolving link between inflammation and neurodegeneration. The authors highlight the clinical challenges and key questions that remain to be addressed.

Neutrophil extracellular traps (NETs) prime macrophages for interleukin-1β production in atherosclerosis.

The intestinal microbiota restrains type 2 immune responses by inducing the development of RORγt-expressing T cells.

Allan Mowat describes a 2005 study that identified the ability of CD103⁺dendritic cells to imprint T cells with gut-homing specificity.

Interleukin-26 mediates direct antimicrobial and immunostimulatory activities of T helper 17 cells.

Exhausted T cells display a phenotype characterized by progressive loss of function, and they can develop following exposure to persistent antigen and/or inflammatory signals during chronic viral infections or cancer. The authors describe the molecular mechanisms of T cell exhaustion and how the exhausted phenotype is different from other dysfunctional states of T cells.

Male and female mice process mechanical pain using distinct neuroimmune mechanisms.

An interferon-γ-mediated immune response is dominant in severe asthma.

NLRP3 functions independently of the inflammasome as a transcriptional regulator of T helper 2 cell differentiation.

CD8⁺T cell exhaustion is associated with a good outcome in autoimmune and inflammatory diseases.

Mammalian hosts have evolved a range of mechanisms that limit the ability of microorganisms to obtain iron and therefore to survive. Here, the authors describe the role of iron in infection and how iron homeostasis is altered as a consequence of nutritional immunity.

This Review details our current understanding of the biology of plasmacytoid dendritic cells (pDCs). The authors describe the mechanisms controlling the development and functions of pDCs and discuss their roles in infection, inflammatory disease and cancer.

Endoplasmic reticulum stress in tumour-associated dendritic cells impairs their ability to activate an antitumour T cell response.

Eicosanoids are bioactive signalling lipids that regulate numerous homeostatic and inflammatory processes. Here, the authors review our current understanding of cellular eicosanoid metabolism and the physiological functions of pro-inflammatory and pro-resolving eicosanoids in infection and inflammation.