Research Highlights

Adenosine regulates thymocyte development and maintains peripheral naive T cells through the regulation of IL-7Rα expression.

CCR4-specific antibodies deplete regulatory T cells and boost antitumour responses in humans.

IgE responses to venom protect animals against potentially lethal subsequent exposures to the venom.

Genes and environment contribute to a vast diversity of human NK cell phenotypes.

Suppression of mTOR signalling can promote immunity to intracellular pathogens.

Phosphorylation of Mef2 controls immune versus metabolic gene expression in infectedDrosophila melanogaster.

Binding of the mucus component mucin 2 to intestinal dendritic cells delivers immunoregulatory signals.

A novel population of CD301b⁺ dendritic cells potentiates T_H2-type immune responses.

Ageing predisposes individuals to macrophage- and TNF-dependent intolerance of cancer immunotherapy.

The presence of memory T_FHcells in the blood correlates with the development of broadly neutralizing antibodies against HIV.

Type 2 ILCs respond to metabolic cues and tune eosinophil numbers to the circadian clock.

Zinc fingers 1 and 4 of the Ikaros protein have differential roles in lymphocyte development and in lymphomagenesis.

A FOXO3-dependent pathway that limits inflammation is associated with disease prognosis in humans.

Intracellular LPS triggers non-canonical inflammasome activation of caspase 11.

Lineage tracing on the basis of DNGR1 expression history defines cells of the conventional DC lineage.

Early development of B cells can occur in the gut in response to resident microorganisms.

The metabolic regulator AMPK controls macrophage skewing during muscle repair.

Lung dendritic cells imprint CD4⁺T cells with lung-homing and gut-homing receptors.

Oxidative damage to self and foreign DNA potentiates its detection by the innate immune system.

TLR4 activation by fibrinogen cleavage products may contribute to allergic airway inflammation.