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For decades, mutant mice have been used to model human disease and to functionally annotate the mammalian genome. Advances in generating mutants on a large scale — through both forward and reverse genetic approaches — have accelerated progress, as documented by this history of mouse mutagenesis.
Theodor Boveri is best remembered for his chromosome theory of heredity. However, the contributions that he and his wife, Marcella O'Grady Boveri, made to the early days of genetics are greater than just this.