Small RNAs are key regulators of gene expression and genome function, with roles in almost every aspect of biology.
Synthetic biology was born just over a decade ago, with the goal of applying engineering principles to biological circuitry.
In the nucleus, DNA is packaged into chromatin through association with histone proteins and this packaging needs to be modulated to enable genes to be expressed.
Zinc finger nucleases (ZFNs) are powerful tools for the directed modification of genomic DNA sequences as ZFNs can be designed to target and cleave specific sequences.
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are ~21 nucleotides in length and control many developmental and cellular processes in eukaryotes.
Our image of the eukaryotic transcriptome is being transformed.
DNA sequencing is undergoing a revolution.
Double-stranded RNA (dsRNA) molecules can be used to induce a potent silencing process, known as RNA interference (RNAi).
The extended major histocompatibility complex (xMHC) on chromosome 6 is essential for adaptive and innate immunity.
The field of 'omics' currently polarizes the community of biologists.