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  • Riccardo Marioni discusses how the publication of Horvath’s epigenetic clock has affected research into ageing, rejuvenation and epigenetic epidemiology.

    • Riccardo E. Marioni
    Journal Club
  • Luis Saraiva recalls a 1997 paper by Krings et al., which reports the sequencing of mitochondrial Neanderthal DNA extracted from a 40,000-year-old bone, enabling the direct study of the relationship between ancient and modern humans.

    • Luis R. Saraiva
    Journal Club
  • Guojie Zhang discusses a seminal paper by Alfred H. Sturtevant, in which he concluded based on his observations in fruitflies that the mutation rate is an evolving parameter.

    • Guojie Zhang
    Journal Club
  • In this Journal Club article, María Ávila-Arcos discusses a paper on a medically relevant genetic variant that was found exclusively in Indigenous populations from the Americas. She describes how this work served as inspiration for the inclusion of more diverse populations in the 1000 Genomes Project.

    • María C. Ávila-Arcos
    Journal Club
  • Lillian Musila highlights a paper by Quick et al., which reported the use of portable nanopore sequencing for on-site, real-time genomic surveillance during the 2014–2016 Ebola virus epidemic.

    • Lillian Musila
    Journal Club
  • Dimple Notani highlights a 1981 paper by Banerji et al. that describes the discovery of viral enhancer elements and that continues to shape her research today.

    • Dimple Notani
    Journal Club
  • In this Journal Club, Yukinori Okada recalls a 1987 publication that introduced a simple conceptual framework, the shared epitope hypothesis, to explain the genetic risk of rheumatoid arthritis conferred by HLA-DRB1 alleles.

    • Yukinori Okada
    Journal Club
  • In this Journal Club article, Geoff Faulkner discusses how a ground-breaking study of LINE-1 mobility in human genomes demonstrated not just a role in disease but also molecular details of the mechanisms of retrotransposition.

    • Geoffrey J. Faulkner
    Journal Club
  • In this Journal Club article, Yana Bromberg discusses an early application of machine learning for protein structure prediction — a paper that shaped her career. It illustrates the value of ensuring that machine learning approaches are rooted in known biological principles.

    • Yana Bromberg
    Journal Club
  • Michael Purugganan reflects on a 100-year-old publication by Nikolai Vavilov, which postulated a new law of genetics from which key evolutionary insights emerged and which guided future molecular genetic investigations.

    • Michael D. Purugganan
    Journal Club
  • In this Journal Club, Itai Yanai discusses key quantitative work characterizing the occurrence and fates of gene duplicates across various species.

    • Itai Yanai
    Journal Club