PrimeViews in 2019

This PrimeView highlights the mechanisms underlying follicular lymphoma, a malignancy of germinal centre B cells.

Diphtheria is an infectious disease caused by toxigenic strains of Corynebacterium diphtheriae. The molecular and geographical epidemiology of the bacteria is constantly evolving and, together with decreased vaccination coverage, could promote the re-emergence of this disease.

Gonorrhoea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae and a major global public health concern. Tackling the disease burden requires a multidisciplinary approach including epidemiology, pathophysiology, diagnosis, prevention and management.

This PrimeView highlights the management strategies for bronchopulmonary dysplasia, a form of chronic lung dysfunction that results from lung and airway injury caused by respiratory support measures in (predominantly premature) newborn babies.

This PrimeView highlights the quality of life concerns that patients with craniopharyngiomas — embryonic tumours that arise along the craniopharyngeal duct in the skull — face.

The main focus of this PrimeView is the prevention of suicide, which includes universal, indicated and selective interventions. This PrimeView accompanies the Primer article on Suicide and Suicide risk by Turecki et al.

This PrimeView accompanies the Primer on Ischaemic stroke by Campbell and colleagues and focuses on the mechanisms of ischaemic stroke.

Gout is a chronic disease of monosodium urate crystal deposition, usually presenting as an acute inflammatory arthritis in response to deposited crystals. This PrimeView highlights evolving approaches to management of gout.

This PrimeView highlights the management of breast cancer, the most frequent malignancy in women.

Fanconi anaemia, ataxia telangiectasia, Nijmegen breakage syndrome and Bloom syndrome are rare, clinically distinct, chromosome instability disorders that predispose to cancer. This PrimeView highlights the clinical features of these disorders, which are clinically distinct and affect quality of life.

Nausea and vomiting of pregnancy and its severe form, hyperemesis gravidarum (HG), are associated with extreme reduction in quality of life. This PrimeView describes the maternal and fetal risks and outcomes.

This PrimeView highlights the mechanisms underlying autosomal dominant tubulointerstitial kidney disease (ADTKD), which is a group of rare diseases characterized by tubular damage and interstitial fibrosis but without glomerular lesions.

Drug-induced liver injury (DILI) is a disorder whereby drugs (including pharmacological therapies, traditional medicines, and herbal or dietary supplements) cause liver damage. This PrimeView highlights how a diagnosis of DILI is made, and the mechanisms leading to it.

This PrimeView highlights the mechanisms that contribute to the initiation and progression of atherosclerosis, the progressive accumulation of fatty and fibrous material in the arterial wall that can lead to cardiovascular disease.

This PrimeView discusses the four types of diabetes insipidus (DI), central, nephrogenic and gestational DI), and primary polydipsia, and how the aetiology influences the management of the disorder.

This PrimeView highlights the treatment of obsessive–compulsive disorder, which can include psychotherapy, psychoeducation, neuromodulation and pharmacological therapy.

This PrimeView highlights the diagnostic criteria for gambling disorder, the first and only formal behavioural addiction to be included in the fifth edition of the Diagnostic and Statistical Manual.

Gestational diabetes mellitus (GDM) is the most common complication in pregnancy and has short-term and long-term effects in both mother and offspring. This PrimeView highlights the definitions, diagnosis and pathophysiology of GDM.

Sarcoidosis is an inflammatory disease of unknown cause involving the formation of granulomas in almost any organ, although typically in the lungs. This PrimeView discusses the epidemiology, pathogenesis, diagnosis and treatment of sarcoidosis.

This PrimeView summarizes the mechanisms of conduct disorder, a psychiatric disorder that is characterized by behaviours that violate the rights of other individuals.