L. Marshall

Sickle cell disease

Sickle cell disease is caused by mutations in HBB (encoding haemoglobin subunit β). The incidence is estimated to be 300,000–400,000 neonates globally each year, the majority in sub-Saharan Africa. 

Latest Primers & PrimeViews

  • Primer |

    This Primer by Pfister and colleagues reviews the molecular genetics, diagnosis and management of medulloblastoma and touches upon the quality of life of patients and future outlooks.

    • Paul A. Northcott
    • , Giles W. Robinson
    • , Christian P. Kratz
    • , Donald J. Mabbott
    • , Scott L. Pomeroy
    • , Steven C. Clifford
    • , Stefan Rutkowski
    • , David W. Ellison
    • , David Malkin
    • , Michael D. Taylor
    • , Amar Gajjar
    •  & Stefan M. Pfister
  • Primer |

    Kaposi sarcoma is a rare cancer that typically presents with multiple pigmented skin lesions, but may take an aggressive course characterised by lesion ulceration, oedema and visceral organ involvement. This Primer describes the epidemiology, clinical features, cellular mechanisms and management of the main forms of Kaposi sarcoma.

    • Ethel Cesarman
    • , Blossom Damania
    • , Susan E. Krown
    • , Jeffrey Martin
    • , Mark Bower
    •  & Denise Whitby
  • Primer |

    Subfertility affects one in six couples worldwide and is associated with emotional distress and reduced quality of life. This Primer by Farquhar and colleagues discusses the causes, diagnosis and treatment of female subfertility.

    • Cynthia M. Farquhar
    • , Siladitya Bhattacharya
    • , Sjoerd Repping
    • , Sebastiaan Mastenbroek
    • , Mohan S. Kamath
    • , Jane Marjoribanks
    •  & Jacky Boivin
  • Primer |

    An estimated 20% of all patients with cancer will develop brain metastases, with the majority of brain metastases occurring in those with lung and breast cancer and melanoma. This Primer describes the mechanisms by which cancer cells migrate to the brain and the key advances necessary to improve the prognosis for patients with brain metastases.

    • Achal Singh Achrol
    • , Robert C. Rennert
    • , Carey Anders
    • , Riccardo Soffietti
    • , Manmeet S. Ahluwalia
    • , Lakshmi Nayak
    • , Solange Peters
    • , Nils D. Arvold
    • , Griffith R. Harsh
    • , Patricia S. Steeg
    •  & Steven D. Chang
  • Primer |

    Coeliac disease is an immune-mediated enteropathy driven by dietary gluten present in wheat, rye and barley. This Primer discusses the risk factors and immune mechanisms of coeliac disease and highlights future treatment options beyond the gluten-free diet.

    • Katri Lindfors
    • , Carolina Ciacci
    • , Kalle Kurppa
    • , Knut E. A. Lundin
    • , Govind K. Makharia
    • , M. Luisa Mearin
    • , Joseph A. Murray
    • , Elena F. Verdu
    •  & Katri Kaukinen
  • Primer |

    Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. This Primer highlights RMS epidemiology and disease mechanisms and presents the state of the art in clinical care, including diagnostics, risk-based disease management and prevention of late treatment effects.

    • Stephen X. Skapek
    • , Andrea Ferrari
    • , Abha A. Gupta
    • , Philip J. Lupo
    • , Erin Butler
    • , Janet Shipley
    • , Frederic G. Barr
    •  & Douglas S. Hawkins

Corrections & Correspondence

  • Author Correction |

    • Massimo Filippi
    • , Amit Bar-Or
    • , Fredrik Piehl
    • , Paolo Preziosa
    • , Alessandra Solari
    • , Sandra Vukusic
    •  & Maria A. Rocca
  • Author Correction |

    • Catherine M. Greene
    • , Stefan J. Marciniak
    • , Jeffrey Teckman
    • , Ilaria Ferrarotti
    • , Mark L. Brantly
    • , David A. Lomas
    • , James K. Stoller
    •  & Noel G. McElvaney
  • Author Correction |

    • Bettina Balint
    • , Niccolò E. Mencacci
    • , Enza Maria Valente
    • , Antonio Pisani
    • , John Rothwell
    • , Joseph Jankovic
    • , Marie Vidailhet
    •  & Kailash P. Bhatia

Collection

Cancer at Nature Research

Bringing the latest research and review articles on cancer published in Nature Research, covering all aspects from disease mechanisms to therapeutic approaches.

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