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    Autoimmunity is an underlying cause of many diseases. This collection of Research, Reviews and News articles from several Nature journals covers the latest advances in genetic and epigenetic research into autoimmunity and autoimmune diseases.

    Image: Susanne Harris

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    Cancer immunotherapy, which encompasses a variety of approaches that mobilise the immune system to seek out and kill cancer cells, is showing substantial potential to transform the treatment of cancer. Articles in this collection highlight the progress being made with several of the most promising immunotherapy approaches and discuss key issues for maximizing their benefits, such as how immunotherapies may be rationally combined with each other or with traditional anticancer drugs.

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    To mark the tenth anniversary of Nature Reviews Drug Discovery, this collection brings together data on key indicators for the field over the past decade, as well as a selection of some of the most highly cited and downloaded articles published in the journal from each of the last ten years.

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    Many of the thousands of rare diseases lack effective treatments. However, economic and regulatory incentives, as well as advances in our understanding of disease aetiology, have encouraged increased investment in the development of drugs for rare diseases — orphan drugs. This special collection from Nature Reviews Drug Discoveryincludes articles that discuss the impact of orphan drug legislation in the United States and Europe, and that review recent therapeutic progress for two groups of rare diseases: neuromuscular disorders and myeloproliferative neoplasias.

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    The rapid growth in the prevalence of type 2 diabetes is increasing the need for effective therapeutic interventions. However, although multiple classes of diabetes drugs are available, achieving long-term control of blood sugar is often a major challenge, in part owing to treatment-limiting adverse effects. With these challenges in mind, this special collection of articles from Nature Reviews Drug Discoveryfocuses on emerging therapeutic approaches and targets for type 2 diabetes.