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Volume 17 Issue 1, January 2020

Volume 17 Issue 1

This issue includes Reviews on chronic coronary artery disease, permanent His bundle pacing, drug-eluting coronary stents and endothelial responses to shear stress in atherosclerosis.

The cover shows aggregated platelets in a fibrinogen matrix imaged by scanning electron microscopy. Image: Rabea Schlüter, University of Greifswald, Germany; Lisa Maletzki and Raila Busch, University Medicine Greifswald, Germany; acknowledgement to Stefan Bock for technical assistance. Cover design: Vicky Summersby.


  • Comment |

    Artificial intelligence (AI) holds promise for cardiovascular medicine but is limited by a lack of large, heterogeneous and granular data sets. Blockchain provides secure interoperability between siloed stakeholders and centralized data sources. We discuss integration of blockchain with AI for data-centric analysis and information flow, its current limitations and potential cardiovascular applications.

    • Chayakrit Krittanawong
    • Albert J. Rogers
    • Sanjiv M. Narayan

Research Highlights


  • Review Article |

    Patients with known cardiovascular disease but no recent acute event are often referred to as having ‘stable’ coronary artery disease. In this Review, Fox and colleagues describe why this concept of stable disease is misleading and should instead be characterized as chronic disease with an increased risk of atherothrombotic events.

    • Keith A. A. Fox
    • Marco Metra
    • Dan Atar
  • Review Article |

    By stimulating the His–Purkinje network directly, His bundle pacing results in synchronized, physiological ventricular activation, which might improve clinical outcomes compared with the use of right ventricular apical pacing. Sharma and colleagues summarize early clinical observations, implantation techniques and outcome data with permanent His bundle pacing.

    • Parikshit S. Sharma
    • Pugazhendhi Vijayaraman
    • Kenneth A. Ellenbogen
  • Review Article |

    This Review outlines the drawbacks and lessons learned from first-generation drug-eluting stents, and then discusses design features and preclinical, pathology and clinical data from newer-generation devices. The authors focus on how evolution in stent design has improved biomaterial–blood interactions and vascular healing.

    • Sho Torii
    • Hiroyuki Jinnouchi
    • Aloke V. Finn
  • Review Article |

    The shear stress generated by flowing blood has major effects on vascular function, with low shear stress promoting vascular dysfunction and atherosclerosis. This Review describes the latest findings on how endothelial cells decode complex shear stress environments to regulate physiological and pathophysiological responses, highlighting the role of pathways involved in embryonic development.

    • Celine Souilhol
    • Jovana Serbanovic-Canic
    • Paul C. Evans



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