This issue contains Reviews on the mechanisms of cardiovascular benefit of SGLT2 inhibitors, myocardial ischaemia–perfusion injury and cardioprotection, coronary vessel formation, and mitral valve regurgitation.

This issue contains Reviews on extracellular vesicles for cardiovascular therapeutics, cardiac natriuretic peptides, pregnancy and cardiovascular disease, and intracellular calcium leak in heart failure and atrial fibrillation.

This issue contains Reviews on device-based therapies for hypertension, non-hyperaemic coronary pressure measurements, congestion in heart failure and environmental determinants of cardiovascular disease.

This issue contains Reviews on COVID-19 and cardiovascular disease, evaluation and management of HFpEF, cardiovascular effects of non-aspirin NSAIDs, and mechanisms of diabetic cardiomyopathy.

This issue contains Reviews on cardiovascular applications of single-cell RNA sequencing and cardiac and vascular toxic effects of cancer therapies, and a Perspectives article describing heart failure as an interstitial cancer.

This issue contains Reviews on T cells in atherosclerosis, endurance exercise and the heart, and diagnostic imaging of cardiac amyloidosis, and a Consensus Statement on quantitative cardiac imaging of myocardial ischaemia.

This issue contains Reviews on neutrophils as regulators of cardiovascular inflammation, cardiomyocyte maturation and implications for regenerative medicine, and care of patients with familial hypercholesterolaemia.

This issue includes a Consensus Statement on the assessment of mitral regurgitation by cardiac MRI and Reviews on the role of inflammation in heart failure and the implications of DCM genetics on heart failure management.

This issue includes Reviews on the epidemiology of inherited arrhythmias, non-atherosclerotic causes of ACS, transcriptional and epigenetic regulation of macrophages in atherosclerosis, and dual-pathway inhibition for prevention of thrombosis.

This issue includes Reviews on clonal haematopoiesis and CVDs, genetics of rheumatic heart disease, saphenous vein grafts in CABG surgery, and NADPH oxidases in CVDs.

This issue includes Reviews on transcatheter aortic valve implantation, pulmonary arterial hypertension, lysine acetyltransferases and deacetylases in cardiovascular disease, and the renin–angiotensin system.

This issue includes Reviews on chronic coronary artery disease, permanent His bundle pacing, drug-eluting coronary stents and endothelial responses to shear stress in atherosclerosis.