This issue includes Reviews on the autonomic nervous system and cardiac arrhythmias, HIV infection and coronary heart disease, and vascular smooth muscle cells in atherosclerosis.

This issue includes Reviews on RNA-based strategies for CVD and the role of aspirin in the primary prevention of CVD, a Timeline article marking 70 years of the Framingham Heart Study, and a Viewpoint article celebrating the 15th anniversary of Nature Reviews Cardiology.

This issue includes Reviews on dietary fats and cardiometabolic disease, polypills for the primary prevention of cardiovascular disease, G protein-coupled receptor kinases as therapeutic targets in the heart, and infective endocarditis.

This issue includes Reviews on molecular mechanisms of arrhythmogenic cardiomyopathy; diagnosis, prognosis and management of tricuspid valve disease; and testosterone replacement therapy and cardiovascular risk.

This issue includes Reviews on animal models of arrhythmia, neuroimmune crosstalk in hypertension, endothelins in cardiovascular biology and therapeutics, and circular RNAs in cardiovascular biology.

This issue includes Reviews on inflammation and its resolution in atherosclerosis, circadian rhythms in cardiovascular biology and disease, management of out-of-hospital cardiac arrest, and mechanisms of postoperative atrial fibrillation.

This issue includes Reviews on T cell co-stimulation and co-inhibition in cardiovascular disease, TRP channels in cardiac health and disease, and mechanical regulation of cardiac myocytes and fibroblasts.

This issue includes Reviews on cardiovascular calcification, percutaneous management of paravalvular leaks, fully bioresorbable vascular scaffolds, and oxidized phospholipids and lipoprotein(a).

This issue includes Reviews on the epidemiology of cardiovascular disease (CVD) in China, sleep deprivation as a risk factor for CVD, mechanisms and treatment of abdominal aortic aneurysm and determinants of stent thrombosis.

This issue includes Reviews on the gut microbiome in heart failure, clinical implementation of PCSK9 inhibitors, platelet biology and clinical targets, and B cells in atherosclerosis.

This issue includes six Year in Review articles, Reviews on adipose tissue in cardiovascular health and disease and computational models in cardiology, and a Consensus Statement on antithrombosis in patients with diabetes.

This issue includes Reviews on cardiac lymphatics, genetics of familial hypercholesterolaemia, nanoimmunotherapy for ischaemic heart disease and targeting mitochondria for cardiovascular disorders.