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A study published in Nature identifies the semaphorin receptor plexin D1 as a novel mechanoreceptor in endothelial cells that regulates vascular function and the site-specific distribution of atherosclerosis.
Macrophages directly contribute collagen to scar formation as part of heart regeneration in zebrafish and heart repair in mice; this finding develops the current paradigm of collagen deposition for scar formation being generated exclusively via macrophage-mediated activation of cardiac fibroblasts to myofibroblasts.
D6PV, a dual apolipoprotein C-II mimetic and apolipoprotein C-III antagonist, increases triglyceride lipolysis in mouse models of hypertriglyceridaemia.
Awareness of the effect of the neighbourhood built environment on cardiovascular diseases is growing. In this Comment, we identify major conceptual, methodological and policy-relevant issues in research related to the built environment and describe potential future directions to improve the scientific rigour of research in this field.
A somatic gene editing therapy for the treatment of Duchenne muscular dystrophy (DMD) improves skeletal and cardiac muscle function and reduces cardiac arrhythmogenic vulnerability in a pig model of DMD and an in vitro model of human DMD.
Long QT syndrome (LQTS) is the most common inherited cardiac arrhythmia and has been associated with mutations in 17 different genes; however, the evidence that many of these genes are actually causative for LQTS is limited or disputed.
Autologous mitochondrial transplantation for myocardial protection is feasible, safe and beneficial; however, the mechanisms by which these effects are achieved are uncertain.
Our understanding of the causes and consequences of pulmonary hypertension is limited. Consequently, its most distinctive forms with the worst prognosis have been the focus for diagnosis and treatment. We highlight the emerging challenge of reframing the prevalence and prognostic implications of pulmonary hypertension, focusing on the optimal therapeutic window to address the high mortality linked to this condition.