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An initial invasive strategy in addition to medical therapy does not reduce the risk of death or nonfatal myocardial infarction or relieve angina symptoms compared with an initial conservative strategy with medical therapy alone in patients with stable coronary artery disease, moderate or severe ischaemia and advanced chronic kidney disease.
Findings from the VICTORIA study show that vericiguat treatment can significantly reduce cardiovascular death or first hospitalization for heart failure in patients with worsening heart failure with reduced ejection fraction.
The addition of an invasive strategy (angiography plus revascularization when feasible) to medical therapy does not reduce the risk of cardiovascular events or death but might reduce symptoms of angina among patients with stable coronary artery disease and moderate or severe ischaemia.
Renal denervation compared with a sham procedure can significantly reduce 24-h and office systolic blood pressure levels in patients with uncontrolled hypertension who are not receiving antihypertensive drugs.
The combination of oral anticoagulation and the antiplatelet drug clopidogrel increases the risk of bleeding after transcatheter aortic valve implantation (TAVI) compared with oral anticoagulation alone, according to the results of the POPular TAVI trial cohort B.
Cybersecurity vulnerabilities of cardiac implantable electronic devices have been an area of increasing concern in the past 4 years. Physicians should be informed of these issues as they evolve so they can counsel their patients with the most accurate and up-to-date information.
The safety and durability of the LDL-cholesterol-lowering effects of inclisiran, a small interfering RNA that inhibits the synthesis of PCSK9 in the liver, have now been confirmed in three phase III clinical trials published in the New England Journal of Medicine.
The available literature suggests that electronic cigarettes (e-cigarettes), although not without risk, might decrease cardiovascular risk in chronic smokers of tobacco cigarettes who switch to e-cigarettes. However, to safeguard our youth, e-cigarettes must be required to meet product standards, all flavourings must be banned and laws regulating e-cigarette sales must be strictly enforced.
A novel metabolite derived from gut microbiota has been shown to promote platelet hyper-responsiveness and modulate platelet function via adrenergic receptors, contributing to increased thrombotic risk.
A surgical mouse model of recurrent myocardial infarction (MI) developed by inducing two sequential MIs in different regions of the same mouse revealed that haematopoietic and innate immune responses are shaped by a preceding MI.
Inhibition of fatty acid metabolism to promote oxidation of glycolysis-derived pyruvate promotes cardiomyocyte proliferation and improves left ventricular function after myocardial infarction.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors, leading to coronavirus disease (COVID-19)-related pneumonia, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Therefore, particular attention should be given to cardiovascular protection during treatment for COVID-19.