Research Highlights

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  • A new study shows that adult mouse cardiomyocytes can be reversibly dedifferentiated into fetal-like cardiomyocytes by forcing the transient expression of four pluripotency factors, which enables cardiomyocytes to re-enter the cell cycle and divide, thereby conferring regenerative capacity to the adult heart.

    • Irene Fernández-Ruiz
    Research Highlight
  • A form of adenine base editing has been used in mouse embryos to correct a genetic variant associated with hypertrophic cardiomyopathy. This approach is potentially safer than other forms of germline gene editing, which carry a risk of off-target editing and the introduction of indels.

    • Gregory B. Lim
    Research Highlight
  • Mice deficient in type 2 innate lymphoid cells have a greater accumulation of inflammatory macrophages and poorer cardiac function after myocardial infarction compared with control mice, indicating a role for this subset of lymphocytes in regulating inflammatory pathways in the injured heart.

    • Karina Huynh
    Research Highlight
  • Two new studies show that pharmacological blood pressure (BP) reduction is effective in older individuals and that a more intensive treatment with a lower BP threshold reduces the incidence of cardiovascular events in older patients with hypertension.

    • Irene Fernández-Ruiz
    Research Highlight
  • The STROKESTOP trial and The LOOP study used different approaches to screen for atrial fibrillation, with the aim of initiating oral anticoagulation to prevent stroke and death.

    • Gregory B. Lim
    Research Highlight
  • In the QUARTET trial, initial treatment with a single pill containing quarter doses of four antihypertensive drugs achieved and maintained a greater blood-pressure-lowering effect than initial monotherapy with full-dose irbesartan.

    • Gregory B. Lim
    Research Highlight
  • Data from the MASTER DAPT trial indicate that the duration of dual antiplatelet therapy can be abbreviated in patients at high risk of bleeding undergoing implantation of a drug-eluting stent, resulting in a reduction in bleeding risk without an increase in ischaemic events.

    • Gregory B. Lim
    Research Highlight
  • A new study now shows that basophils can influence cardiac remodelling after myocardial infarction. Despite their low number in the injured myocardium, basophils strongly affected other immune cells involved in cardiac repair and remodelling in mice, promoting cardiac healing by facilitating the polarization of reparative macrophages.

    • Irene Fernández-Ruiz
    Research Highlight
  • A single-cell RNA-sequencing study in mice shows that, after myocardial infarction, the activated epicardium contains heterogeneous cell populations with distinct gene-expression profiles and paracrine signalling potential, which contribute to the cardioprotective and regenerative responses to ischaemic injury.

    • Gregory B. Lim
    Research Highlight
  • Patients with cardiovascular disease who live with socioeconomic disadvantage face barriers to healthy living. A new study assessing social disadvantage burden reveals that this patient population has poor adherence to COVID-19 risk-mitigation recommendations.

    • Ciarán Martin Fitzpatrick
    Research Highlight
  • Treatment with atglistatin, an inhibitor of adipose triglyceride lipase (ATGL) activity, has cardioprotective effects against catecholamine-induced cardiac damage in mice, according to a new study. Atglistatin inhibited adipose ATGL activity but had no effect on cardiac ATGL, indicating that its cardioprotective effects are mediated by non-cardiac actions.

    • Irene Fernández-Ruiz
    Research Highlight