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Influenza vaccination shortly after a myocardial infarction or in high-risk coronary heart disease reduces the risk of future cardiovascular events, according to findings from the IAMI trial.
Ablation plus cardiac resynchronization therapy is superior to pharmacological therapy in reducing mortality in patients with atrial fibrillation and a narrow QRS complex who were hospitalized with heart failure.
Data from the MASTER DAPT trial indicate that the duration of dual antiplatelet therapy can be abbreviated in patients at high risk of bleeding undergoing implantation of a drug-eluting stent, resulting in a reduction in bleeding risk without an increase in ischaemic events.
High levels of extracellular glucose induce trained immunity in macrophages, promoting a pro-atherosclerotic phenotype that persists even after normalization of glucose levels.
A new study now shows that basophils can influence cardiac remodelling after myocardial infarction. Despite their low number in the injured myocardium, basophils strongly affected other immune cells involved in cardiac repair and remodelling in mice, promoting cardiac healing by facilitating the polarization of reparative macrophages.
A new study shows that gene therapy to knock down endogenous Hippo signalling in cardiomyocytes induces cardiac tissue renewal and improves heart function after myocardial infarction in adult pigs.
A single-cell RNA-sequencing study in mice shows that, after myocardial infarction, the activated epicardium contains heterogeneous cell populations with distinct gene-expression profiles and paracrine signalling potential, which contribute to the cardioprotective and regenerative responses to ischaemic injury.
Patients with cardiovascular disease who live with socioeconomic disadvantage face barriers to healthy living. A new study assessing social disadvantage burden reveals that this patient population has poor adherence to COVID-19 risk-mitigation recommendations.
Treatment with atglistatin, an inhibitor of adipose triglyceride lipase (ATGL) activity, has cardioprotective effects against catecholamine-induced cardiac damage in mice, according to a new study. Atglistatin inhibited adipose ATGL activity but had no effect on cardiac ATGL, indicating that its cardioprotective effects are mediated by non-cardiac actions.
A new study has identified a novel microRNA present in the blood that could potentially be used as a diagnostic test to distinguish between acute myocarditis and myocardial infarction.
PCSK9 inhibitors are a class of cholesterol-lowering drugs that regulate LDL-receptor degradation. Three new studies show successful reduction of PCSK9 levels by different approaches that all resulted in the lowering of LDL-cholesterol levels.
Mineralocorticoid-receptor antagonism with the novel drug finerenone reduces the risk of new-onset atrial fibrillation or flutter in patients with chronic kidney disease and type 2 diabetes mellitus, according to a secondary analysis of the FIDELIO-DKD trial.
Surgical occlusion of the left atrial appendage reduces the risk of ischaemic stroke among patients with atrial fibrillation who had undergone cardiac surgery for another indication.
Endovascular, ultrasound-based renal sympathetic denervation reduces blood pressure in patients with drug-resistant hypertension, according to data from the RADIANCE-HTN TRIO trial.
The CD200 inhibitory immune checkpoint promotes arterial homeostasis and reduces atherosclerotic plaque progression and inflammation in mice by limiting the excessive supply, recruitment and activation of monocytes and macrophages during atherogenesis, according to a new study.
A tailored cardiac rehabilitation programme resulted in a greater improvement in physical function than usual care among elderly frail patients who were hospitalized for acute decompensated heart failure
A new study shows that male rats are more susceptible to cardiac fibrosis in response to chronic adrenergic stimulation than female rats, probably as a result of the increased myofibroblast activation in male hearts, and suggests that sex hormones do not to control the cardiac fibroblast response in this setting.
The histone reader PHF7 binds to cardiac super-enhancers and is a strong activator of the reprogramming of adult cardiac fibroblasts to induced cardiac-like myocytes.
