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Immediate complete revascularization is as safe and effective as staged complete revascularization in patients with acute coronary syndrome and multivessel disease, according to findings from the BIOVASC trial.
In the Evolut Low Risk study, transcatheter aortic valve implantation in low-risk patients with severe aortic stenosis compared favourably with surgical aortic valve replacement in terms of all-cause mortality or disabling stroke at 3 years.
According to findings from the PULSED AF trial, pulsed field ablation for atrial fibrillation is associated with a very low incidence of serious procedure-related adverse events and has an effectiveness consistent with that of established thermal ablation methods.
Findings from the STELLAR trial show that the addition of sotatercept to background therapy in patients with pulmonary arterial hypertension significantly improved exercise capacity compared with placebo.
Deisseroth and colleagues used a novel optogenetic system to pace the heart and determine whether an increase in heart rate can evoke anxiety-like behaviours.
Findings from the DREAM-HF trial, the largest clinical trial of cell therapy in heart failure with reduced ejection fraction (HFrEF) to date, suggest that cardiac therapy with mesenchymal precursor cells might benefit patients with HFrEF, particularly those with inflammation.
The non-nutritive sweetener erythritol, a widely used sugar substitute, is associated with an increased risk of cardiovascular disease, including myocardial infarction and stroke, according to a new study.
Adenine base editing can be used to correct a genetic variant in preclinical models of hypertrophic cardiomyopathy, and this approach could be applied to other monogenic cardiac diseases.
A legally mandated preparticipation screening programme for all young people in Italy engaging in competitive sports has resulted in a very low rate of sports-related cardiac arrest and sudden cardiac death.
Researchers have engineered a wearable device that adheres to the skin and uses ultrasound imaging and a deep learning model to produce a dynamic, real-time assessment of cardiac function.
A subpopulation of cardiac-resident macrophages protect the heart against sepsis-induced cardiomyopathy by scavenging dysfunctional mitochondria ejected from cardiomyocytes; modulation or administration of these macrophages might be a potential therapeutic strategy.
In treatment-naive patients with essential hypertension, supplementation with prebiotic acetylated and butyrylated high amylose maize starch significantly reduces systolic blood pressure levels compared with placebo.
A new study shows that age-dependent nuclear remodelling in cardiomyocytes (via age-related loss of nuclear lamins) contributes to cardiac dysfunction through a process that is conserved in flies, mice and nonhuman primates.
A machine learning model trained using clinical data from electronic health records generated a novel in silico quantitative score for coronary artery disease
An intravascularly infused extracellular matrix preparation binds to leaky microvasculature, thereby localizing to inflamed tissues and promoting repair and regeneration, and potentially healing damaged tissues ‘from the inside out’.
Cytotoxic CD8+ T cells specific for the cardiac protein α-myosin heavy chain have a key role in immune-checkpoint-inhibitor-associated myocarditis, according to a study published in Nature.
In patients with paroxysmal, untreated atrial fibrillation (AF), first-line cryoballoon ablation is associated with a lower incidence of persistent AF compared with antiarrhythmic drug therapy, according to the 3-year follow-up data from the EARLY-AF trial.
In patients with chronic limb-threatening ischaemia who had an adequate conduit for vein bypass, bypass surgery is associated with fewer adverse events or deaths than an endovascular procedure, according to findings from the BEST-CLI trial.
