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In the multicentre, randomized, placebo-controlled RAPID trial, use of symptom-prompted, self-administered, intranasally delivered etripamil was safe and superior to placebo for the conversion of paroxysmal superventricular tachycardia to sinus rhythm.
Testosterone-replacement therapy in men with hypogonadism and a high risk of cardiovascular disease does not increase the risk of adverse cardiac events, according to data from the TRAVERSE trial.
New research shows that the reduced risk of major adverse cardiovascular events associated with light or moderate alcohol consumption is partly mediated by attenuation of the activity of a stress-related neural network.
An antibody-based therapy for transthyretin amyloid cardiomyopathy is safe, and initial findings from a phase I trial suggest that it might deplete amyloid deposits in the heart.
In a diverse population of patients with heart failure with mildly reduced or preserved ejection fraction stabilized after a recent worsening heart failure event, treatment with sacubitril–valsartan induces greater reductions in plasma NT-proBNP levels and is associated with clinical benefit compared with valsartan alone, despite a higher rate of symptomatic hypotension.
The essential omega-6 polyunsaturated fatty acid γ-linolenic acid present in maternal milk coordinates cardiac adaptation and survival in newborn mice, according to a new study.
Results from the MONITOR-HF trial show that remote monitoring of pulmonary artery pressure using the implantable CardioMEMS sensor in patients with chronic heart failure improves quality of life and reduces hospitalizations.
In a mouse model of atherosclerosis, a selective monoclonal antibody that blocks the binding of LDL to activin receptor-like kinase 1 reduced plaque formation in the aorta.
Simvastatin improves endothelial cell function by inhibiting endothelial-to-mesenchymal transition through an epigenetic regulatory mechanism, according to a new study.
Findings from the VIRGO study reveal that young women with acute myocardial infarction are more likely to be rehospitalized within 1 year compared with similarly aged men.
Hyperphosphorylation of tau in the heart reduces the tyrosination of microtubules, leading to myocardial stiffness and heart failure. This novel mechanism of diastolic dysfunction parallels the aggregation of tau in the brain that leads to Alzheimer disease and might be amenable to treatment using monoclonal antibodies against tau.
An artificial intelligence-guided workflow for initial evaluation of left ventricular ejection fraction in echocardiography is non-inferior to initial assessment by a sonographer, according to findings from a blinded, randomized, non-inferiority clinical trial.
Desmosomal protein degradation that occurs via a mechanism involving the ubiquitin–proteasome system might underlie the development of arrhythmogenic cardiomyopathy.
In the CLEAR Outcomes trial, bempedoic acid lowered plasma LDL-cholesterol levels and reduced the incidence of major adverse cardiovascular events in individuals who were intolerant to statin therapy.
Tricuspid transcatheter edge-to-edge repair in patients with severe tricuspid regurgitation improved quality of life and reduced disease severity compared with medical therapy
A wrist-worn, transdermal sensor can be used to measure plasma levels of cardiac troponin I, potentially facilitating the diagnosis of myocardial infarction.
In patients with complex coronary lesions, percutaneous coronary intervention guided by intravascular imaging improved cardiovascular outcomes compared with percutaneous coronary intervention guided by angiography.
MK-0616, an oral inhibitor of PCSK9, safely and effectively lowers plasma levels of LDL cholesterol in a dose-dependent manner in patients with hypercholesterolaemia.