Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In this Tools of the Trade article, Alexandros P. Drainas describes the development and use of EpicMIBI, a multiplexed imaging technology that enables the study of spatial clonality in cancer.
In this Tool of the Trade article, Mateusz Legut describes the development and use of OverCITE-seq, a new single-cell multiomics approach enabling the high-throughput quantification of the transcriptome and surface antigens in cells expressing a library of open reading frames.
Blanpain and colleagues provide evidence that the small RHO GTPase, RHOJ, mediates resistance to chemotherapy in tumour cells that have undergone epithelial-to-mesenchymal transition by enabling these cells to tolerate replicative stress and promote DNA damage repair.
In a recent study on castration-resistant prostate cancer, Cui et al. uncover a role for cancer-associated fibroblasts (CAFs) in inducing androgen synthesis in prostate cancer cells.
In a recent Nature study, Hill et al. provide mechanistic evidence that air pollution promotes lung tumorigenesis in cells with pre-existing oncogenic mutations.
Ruf et al. discuss the emerging roles of innate lymphoid cells and innate-like T cells in cancer immunity. The authors highlight their role in bridging adaptive and innate immunity, as well as their potential as immunotherapeutic targets.
This Review outlines how the developmental pathways that are involved in melanocyte development and skin pigmentation are highjacked by melanoma cells to drive melanomagenesis, progression and therapy resistance.
Although metastasis is the leading cause of cancer-related deaths, our understanding of the process is limited. In this Review, Hebert et al. discuss the key features of various models of metastasis, highlighting their advantages and disadvantages for further dissecting mechanisms of metastasis and developing metastasis-targeted therapies.
Eukaryotic initiation factor 4F (eIF4F) controls the translation of a subset of transcripts that include those encoding oncogenic proteins. In this Perspective article, Bartish et al. discuss the implications of targeting eIF4F on immune and stromal cells in the tumour microenvironment. In addition to discussing data from cancer models, the authors incorporate extensive data from non-cancer contexts to identify potential desirable or unwanted effects of eIF4F inhibition in these cells.
