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In this Tools of the Trade article, Lee describes Select-seq, a novel method for generating epitranscriptomic data from microniches within the tumour. The author reveals how the method can be used to identify novel biomarkers from rare cell subpopulations such as cancer stem cells in tumours.
In this Tools of the Trade article, Susan Bullman describes the development and use of INVADEseq, a single-cell RNA sequencing approach that facilitates the simultaneous capture of both eukaryotic and bacterial transcripts in host cells to functionally understand the intratumoural microbiota.
In this study, Linde et al. demonstrate how therapeutic activation of neutrophils leads to tumour eradication and reduced metastatic seeding in multiple mouse models of cancer.
Altea-Manzano et al. find that factors secreted by primary breast tumours or high-fat diet feeding enriches the fatty acid palmitate in distant organs, which primes pre-metastatic niches enabling metastatic growth.
In this study, the authors investigate the mechanistic basis of alternative telomere lengthening, a process that certain cancer cells use to overcome telomere shortening.
This Review outlines how the profound intertumoural heterogeneity in immune landscapes of tumours is shaped by cancer cell-intrinsic alterations and highlights how the crosstalk between these two continuously evolving systems not only challenges therapy success of immunomodulatory drugs but also provides the basis for new therapeutic strategies to overcome immune evasion.
Myeloid cells in the tumour microenvironment strongly influence tumour progression, and targeting these cells has been a key clinical focus. In this Review, Barry et al. discuss preclinical and clinical data on myeloid-targeting therapies, with a focus on how understanding context-specific effects might aid the design of successful clinical trials for these drugs.
Clinical correlative data and a plethora of preclinical studies of cancers have shown that both tumour-associated and metastasis-associated macrophages play an important role in promoting cancer. In this Perspective article, Cassetta and Pollard chronologically explore the evolution of our understanding of tumour-associated macrophage biology and enabling technologies.
In this Perspective, Tsoumakidou explores the emerging role of cancer-associated fibroblasts as positive regulators of the adaptive immune system in cancer.
