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In this Comment, Deb et al. explore ‘cancer art’ projects that enable new conversations for a broader audience, advocate for policy and disparity issues, and lead to creative innovations for research.
Yang, Zhang, Luan et al. report that a germline variant that increases the risk of Philadelphia chromosome-like acute lymphoblastic leukaemia upregulates GATA3 expression, which changes chromatin accessibility to allow activation of oncogenic pathways.
Kerdidani et al. have identified MHC-II-expressing cancer-associated fibroblasts in non-small-cell lung cancers where they appear to promote anti-tumour immunity.
Asrir et al. show that tumour-associated high endothelial venues (TA-HEVs) in tumour-bearing mice are points of entry for lymphocytes, and increasing TA-HEVs frequency and maturation improves immune checkpoint blockade.
Xie and Gu discuss a study that reported the development of a CAR T therapy-based multi-antigen targeting strategy for the treatment of glioblastoma (GBM) in mice, overcoming antigen specificity and heterogeneity.
This Review discusses the mechanisms underlying the immune response to melanomas, as well as the mechanisms of response and resistance of these tumours to immunotherapies. The lessons learned in melanoma may apply to other tumour types.
Our understanding of ependymomas, which are rare tumours of the central nervous system, has increased substantially over the past 10 years. This Review discusses important biological features of ependymoma as well as key oncogenes, tumour suppressors and epigenetic changes that could potentially be exploited to improve therapy.
This Review discusses the complex biology of the family of kallikrein-related peptidases and their context-dependent functions in cancer and the tumour microenvironment, as well as their role in tumour immune suppression and resistance to cancer therapy.
Liquid–liquid phase separation (LLPS) has been revealed as a widespread mechanism underlying the spatiotemporal coordination of biological activities in cells. This Perspective discusses how LLPS shapes the biochemical landscape of cancer cells, providing insight into emerging findings of dysregulated LLPS promoting cancer pathology.