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Pleguezuelos-Manzano et al. have discovered a mutational signature in colorectal cancer that arises following exposure to genotoxic pks+E. coli, firmly establishing causality.
Hoekstra et al. and Thibaut et al., both reporting in Nature Cancer, show that interferon-γ secreted by tumour-reactive T cells diffuses into the tumour microenvironment and acts on remote tumour cells to modify tumour behaviour.
This Review outlines the recent advances in the creation of both combinatorial transgenic cancer models in zebrafish and zebrafish patient-derived xenograft models, and argues that these models have potential to be used as avatars for precision oncology.
This Perspective discusses the development of cachexia in the context of cancer progression, providing insight into how circulating factors contribute to this syndrome, and exploring how signals involved in metastasis can potentially amplify cachexia development.
This Perspective outlines our current understanding of how the bone marrow niche contributes to both the initiation and the progression of haematological malignancies and suggests guidelines for the field which might help to overcome existing research challenges.
