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Cell competition occurs in the thymus to promote natural turnover of older progenitor cells, and mice lacking such competition develop T cell acute lymphoblastic leukaemia (T-ALL).
Adleret al. identify PRPF6as an important driver of colon cancer cell growth and suggest it promotes proliferation by preferential splicing of growth-promoting genes.
This paper indicates that a global loss of microRNAs reduces the growth of non-small-cell lung cancer cellsin vivoowing to the suppression of tumour angiogenesis.
Scott Lowe and colleagues have found that increased expression of platelet-derived growth factor receptor-β in pancreatic cancer cells is mediated by DNA binding and structural mutants of p53 and that this contributes to metastasis.
The bromodomain and extraterminal (BET) family of chromatin readers are important for androgen receptor-mediated transcription, and BET inhibition by the small molecule JQ1 reduces tumour volume in a mouse model of castration-resistant prostate cancer.
Kunyoo Shin, Philip Beachy and colleagues have tracked the development of invasive bladder cancer in mice and show that basal stem cells, which express sonic hedgehog, initiate this disease.
The cohesin complex is involved in sister chromatid cohesion, as well as other processes, such as transcriptional regulation. Mutations in genes encoding cohesin subunits and cohesin regulators have recently been identified in several tumour types. This Progress article discusses the roles of the cohesin complex and how its mutation might contribute to cancer progression.
There is a clinical need for biomarkers to identify women with progressive cervical intraepithelial neoplasia (CIN) lesions to tailor clinical management and prevent overtreatment. This Review discusses the advances in understanding genetic and epigenetic alterations that underlie cervical cancer development, which offer opportunities for the molecular distinction of cervical cancer precursor lesions.
This Review highlights how intravital microscopy techniques have been used in living animals (predominantly mice) to unravel fundamental and dynamic aspects of several processes that are crucial for the initiation and progression of tumours, and it discusses future perspectives for these techniques.
This Opinion article discusses emerging evidence that nicotine has tumour-promoting activities and may also have direct mutagenic effects, in addition to its effects in combination with tobacco carcinogens. The author suggests that these data should be considered in the development and evaluation of non-tobacco nicotine products.
Emerging data indicate that hypoxia and the extracellular matrix (ECM) together might have a crucial role in metastasis. In this Opinion article the authors suggest a model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.
The burden of chemotherapy-associated toxicity is well recognized, but we have relatively few tools that increase the precision of anticancer drug prescribing. This article proposes that broader agnostic analyses to systematically correlate germline genetic variants with adverse events in large, well-defined cancer populations might improve the current situation.
