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Stage MS neuroblastoma is unique in that it regresses without treatment. Could a better understanding of the biology of these tumours inform how high-risk neuroblastoma and other paediatric malignancies are treated?
Julian Downward and colleagues have found that theHmga2RNA contributes to lung cancer development and progression in mice through its function as a competing endogenous RNA (ceRNA).
Mice in which p53, PTEN and BRCA1 (or BRCA2) are inactivated specifically in fallopian tube secretory epithelial cells develop tumours that are highly similar to human high-grade serous ovarian carcinomas.
Two papers report that mutations in calreticulin occur in most patients withJAK2−essential thrombocythemia and primary myelofibrosis, which are two common myeloproliferative neoplasms.
Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of cell fate determination and differentiation in stem and progenitor cells. The ability of ID proteins to function as central 'hubs' for the coordination of multiple cancer hallmarks is establishing them as therapeutic targets and biomarkers in specific types of human tumours.
The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups. These studies have highlighted key distinctions, but also some commonalities, which are discussed in this Review.
Patricia L. M. Dahia gives an overview of insights learned from the study of pheochromocytomas and paragangliomas, which carry the highest degree of heritability of all human tumours.
The cadherin superfamily includes many proteins other than E-cadherin. These cadherins are very diverse in both structure and function, and their mutual interactions seem to influence cancer development and progression in complex and versatile ways.
In this Timeline, the authors discuss the identification of tumour antigens that are recognized by T lymphocytes and how these findings can be effectively and safely transferred to the clinic.
