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The findings from a preliminary report on a Phase I clinical trial of a targeted small interfering RNA drug and the use of an antagomir to target a microRNA associated with metastasis are discussed.
Perrotti and colleagues identify two mechanisms by which miR-328 regulates the expression of its targets, which has implications for the progression of CML.
There have been substantial advances in the understanding of the basic biology and pathogenesis of malignant glioma and medulloblastoma over the past two decades. This Review summarizes these developments in the context of the molecular classification of these types of brain cancer and discusses the implications for the design of new treatment regimens.
Recent reports have identified the ubiquitin-editing enzyme A20 as a crucial tumour suppressor in various lymphomas. This Review analyses how deregulation of ubiquitylation in the NF-κB signalling pathway can promote tumorigenesis.
Key roles in cancer development have been established for PI3K and PTEN — enzymes that regulate the levels of phosphatidylinositol-3,4,5-trisphosphate, but several other phosphoinositide-modifying enzymes have been implicated in the generation and progression of tumours. New insights into the mechanisms and the extent of their involvement in cancer are summarized in this Review.
Over the past 40 years, genetic studies have provided important insights into the genetic architecture of common cancers. Recent genome-wide studies have identified numerous cancer susceptibility genes and led to a shift from single-gene models to multigenic models of cancer risk.
Hox genes are a highly conserved subgroup of the homeobox superfamily that regulate numerous processes including development, apoptosis, differentiation and cell motility. Aberrations in Hox gene expression have been reported in malignancy and this Opinion article discusses our current knowledge of these genes in tumour development and metastasis.
Despite widespread interest, few serum biomarkers have been introduced to the clinic over the past 20 years. Will a global biomarker discovery platform that mines all possible sources for biomarkers be more useful in the search for promising ovarian cancer biomarkers?
