Volume 10 Issue 1, January 2010

A crucial aspect of tumour biology, inflammation, is often overlooked in biomarker studies and needs to be urgently addressed.

Signals from EphB receptors that trigger cell proliferation and migration are mediated by two distinct downstream pathways.

Hyperactive AID can result in widespread genomic damage and lymphoma.

Several papers find that YAP1 has many important roles in tumorigenesis and tumour progression.

How does ZEB1 regulate self-renewal and migration?

TAp63 induces senescence and suppresses tumour growth in vivo.

Missense mutations of IDH1 confer oncogenic gain-of-function properties.

The integrins regulate a diverse array of cellular functions that are crucial to the initiation, progression and metastasis of solid tumours. This Review discusses the exciting developments in targeting integrins, including the recent initiation of a Phase III trial for an integrin antagonist in patients with glioblastoma.

Epigenetic modifications, including DNA methylation and histone modifications, as well as microRNAs, contribute to the development of acute leukaemias. This Review describes the current understanding of epigenetic changes (including microRNA regulation) in acute leukaemias, with a particular focus on those characterized by balanced chromosomal aberrations.

Many factors, including genetic and epigenetic alterations, antigenic drive and the microenvironment, are crucial in the initiation and progression of chronic lymphocytic leukaemia (CLL). How will our growing understanding of CLL biology lead to the translation of therapeutic targets and prognostic markers into clinical practice?

Oncogene-induced senescence was first seen in cultured cells. However, since the initialin vitro observation of this phenomenon, it has been shown to occur in both mouse and human tumours. What do we know about tumour cell senescence in vivo, and how might this be exploited therapeutically?

This article proposes a weight-of-evidence based classification system for identifying individual genes in an amplified region of the genome that contribute to cancer development. The 77 genes identified using this approach have been further subdivided into different gene classes.

Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. This Perspective summarizes the emerging role of the transcription factor ATF2 as part of the AP1 complex in tumorigenesis.