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Wanget al. show differential requirements for the glycolytic enzymes pyruvate kinase M2 and lactate dehydrogenase A in maintaining haematopoietic stem cells and progenitor cells. Although this difference does not seem to apply to leukaemias derived from these two different cell populations, leukaemia cells are more sensitive to glycolysis inhibition than normal cells.
Chenet al. have shown that growth of isocitrate dehydrogenase 1 (IDH1)-mutant gliomas is promoted by expression of glutamate dehydrogenase 2 (GLUD2) protein.
A study inJAMAhas found that women with unilateral breast cancer who undergo double mastectomies do not have better outcomes than those who undergo lumpectomy followed by radiation.
Vagal innervation promotes tumorigenesis via WNT signalling mediated by muscarinic acetylcholine receptor 3 (M3R) in gastric cancer. Denervation, therefore, might represent a feasible strategy to control this disease.
Rampiaset al. show that Notch signalling is frequently inactivated in human bladder cancers and its loss can promote tumorigenesis in mice through suppressing transcription of phosphatases that normally function to inhibit ERK signalling and proliferation.
Acetoet al. demonstrate that in mouse models of breast cancer, clusters of circulating tumour cells (CTCs) are oligoclonal and are substantially more likely to give rise to metastases than single CTCs. CTC clusters also correlate with reduced survival in patients with breast and prostate cancer.
Administration of autologous gene-modified haematopoietic stem cells (HSCs) improves treatment tolerance and outcome in glioblastoma overexpressing methylguanine methyltransferase (MGMT) and treated with O6-benzylguanine and temozolomide.
Liet al. find that fructose-1,6-bisphosphatase 1 (FBP1) levels are uniformly reduced in clear cell renal cell carcinoma (ccRCC), identifying a new mechanism of metabolic reprogramming in this cancer type.
